PMID- 25287799
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20141007
IS  - 1878-7487 (Electronic)
IS  - 1752-928X (Linking)
VI  - 27
DP  - 2014 Oct
TI  - Does beta-APP staining of the brain in infant bed-sharing deaths differentiate these 
      cases from sudden infant death syndrome?
PG  - 46-9
LID - S1752-928X(14)00144-9 [pii]
LID - 10.1016/j.jflm.2014.07.006 [doi]
AB  - Archival cerebral tissue from infants whose deaths were attributed to sudden 
      infant death syndrome (SIDS) from South Australia and Western Denmark were 
      stained for beta-amyloid precursor protein (beta-APP) and graded according to a simple 
      scoring chart. The resulting APP scores were correlated with sleeping situation 
      (shared vs. alone) showing a significantly higher amount of beta-APP staining in the 
      non-bed-sharing, than in the bed-sharing infants (Mann-Whitney, Australia: 
      p = 0.0128, Denmark: p = 0.0014, Combined: p = 0.0031). There was also a marked 
      but non-significant difference in sex distribution between bed-sharers and 
      non-bed-sharers with a male to female ratio of 1:1 in the first group and 2:1 in 
      the latter. Of 48 Australian and 76 Danish SIDS infants, beta-APP staining was 
      present in 116 (94%) cases. The eight negative cases were all from the Danish 
      cohort. This study has shown that the amount of beta-APP staining was significantly 
      higher in infants who were sleeping alone compared to those who were bed-sharing 
      with one or more adults, in both an Australian and Danish cohort of SIDS infants. 
      Whether this results from differences in the speed with which these infants die, 
      differences in lethal mechanisms involving possible accidental asphyxiation in 
      shared sleepers, or differences in the number of previous hypoxic-ischemic 
      events, remains to be clarified.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Jensen, Lisbeth Lund
AU  - Jensen LL
AD  - Discipline of Anatomy and Pathology, The University of Adelaide, Frome Road, SA 
      5005, Australia; Department of Forensic Medicine, Aarhus University, 
      Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark; The Department of Pathology, 
      Aarhus University Hospital, Norrebrogade, 8000 Aarhus C, Denmark. Electronic 
      address: lislunjn@rm.dk.
FAU - Banner, Jytte
AU  - Banner J
AD  - Department of Forensic Medicine, Aarhus University, Brendstrupgaardsvej 100, 8200 
      Aarhus N, Denmark; Department of Forensic Medicine, University of Copenhagen, 
      Frederik V's Vej 11, 2100 Copenhagen East, Denmark.
FAU - Byard, Roger W
AU  - Byard RW
AD  - Discipline of Anatomy and Pathology, The University of Adelaide, Frome Road, SA 
      5005, Australia.
LA  - eng
PT  - Journal Article
DEP - 20140731
PL  - England
TA  - J Forensic Leg Med
JT  - Journal of forensic and legal medicine
JID - 101300022
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Australia
MH  - *Beds
MH  - Brain/*metabolism
MH  - Denmark
MH  - Female
MH  - Forensic Pathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Sex Distribution
MH  - *Sleep
MH  - Staining and Labeling
MH  - *Sudden Infant Death
OTO - NOTNLM
OT  - Asphyxia
OT  - Bed sharing
OT  - Cosleeping
OT  - Hypoxic-ischemia
OT  - SIDS
OT  - beta-APP
EDAT- 2014/10/08 06:00
MHDA- 2015/06/16 06:00
CRDT- 2014/10/08 06:00
PHST- 2014/04/08 00:00 [received]
PHST- 2014/07/03 00:00 [revised]
PHST- 2014/07/22 00:00 [accepted]
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - S1752-928X(14)00144-9 [pii]
AID - 10.1016/j.jflm.2014.07.006 [doi]
PST - ppublish
SO  - J Forensic Leg Med. 2014 Oct;27:46-9. doi: 10.1016/j.jflm.2014.07.006. Epub 2014 
      Jul 31.