PMID- 25288495
OWN - NLM
STAT- MEDLINE
DCOM- 20150722
LR  - 20220409
IS  - 1464-3391 (Electronic)
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 22
IP  - 21
DP  - 2014 Nov 1
TI  - Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C 
      (MrgC) receptors.
PG  - 5831-7
LID - S0968-0896(14)00671-3 [pii]
LID - 10.1016/j.bmc.2014.09.025 [doi]
AB  - A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were 
      synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 
      receptors. As predicted from the previously established species specificity, 
      these peptidomimetics were found to be devoid of MrgX1 agonist activity. In 
      contrast, these compounds acted as agonists of MrgC and/or MrgC11 with varying 
      degrees of potency. These new peptidomimetics should complement the existing 
      small molecule human MrgX1 agonists and enhance our ability to assess the 
      therapeutic utility of targeting Mrg receptors in rodent models.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Hin, Niyada
AU  - Hin N
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Alt, Jesse
AU  - Alt J
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Zimmermann, Sarah C
AU  - Zimmermann SC
AD  - Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Delahanty, Greg
AU  - Delahanty G
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Ferraris, Dana V
AU  - Ferraris DV
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Rojas, Camilo
AU  - Rojas C
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States.
FAU - Li, Fengxian
AU  - Li F
AD  - Center for the Study of Itch and Departments of Anesthesiology and Anatomy & 
      Neurobiology, Washington University School of Medicine, St Louis, MO 63110, 
      United States.
FAU - Liu, Qin
AU  - Liu Q
AD  - Center for the Study of Itch and Departments of Anesthesiology and Anatomy & 
      Neurobiology, Washington University School of Medicine, St Louis, MO 63110, 
      United States.
FAU - Dong, Xinzhong
AU  - Dong X
AD  - The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 
      Baltimore, MD 21205, United States.
FAU - Slusher, Barbara S
AU  - Slusher BS
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States; Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, 
      United States.
FAU - Tsukamoto, Takashi
AU  - Tsukamoto T
AD  - Brain Science Institute, Johns Hopkins University, Baltimore, MD 21205, United 
      States; Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, 
      United States. Electronic address: ttsukamoto@jhmi.edu.
LA  - eng
GR  - R01 NS054791/NS/NINDS NIH HHS/United States
GR  - 2R01NS054791/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140919
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (MrgC11 protein, mouse)
RN  - 0 (Mrgprc protein, rat)
RN  - 0 (Neuropeptides)
RN  - 0 (Peptidomimetics)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Small Molecule Libraries)
RN  - 0 (mas-related gene-X1 receptor, human)
RN  - 34388-59-5 (arginylphenylalaninamide)
SB  - IM
MH  - Animals
MH  - HEK293 Cells
MH  - Humans
MH  - Mice
MH  - Neuropeptides/chemical synthesis/*chemistry/metabolism
MH  - Peptidomimetics/pharmacology
MH  - Protein Binding/drug effects
MH  - Rats
MH  - Receptors, G-Protein-Coupled/*agonists/genetics/metabolism
MH  - Small Molecule Libraries/chemical synthesis/chemistry/metabolism/pharmacology
MH  - Transfection
PMC - PMC4254045
MID - NIHMS629545
OTO - NOTNLM
OT  - Agonist
OT  - Arginine mimetic
OT  - Mas-related gene (Mrg) receptors
OT  - Peptidomimetic
EDAT- 2014/10/08 06:00
MHDA- 2015/07/23 06:00
PMCR- 2015/11/01
CRDT- 2014/10/08 06:00
PHST- 2014/07/27 00:00 [received]
PHST- 2014/09/05 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/07/23 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0968-0896(14)00671-3 [pii]
AID - 10.1016/j.bmc.2014.09.025 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2014 Nov 1;22(21):5831-7. doi: 10.1016/j.bmc.2014.09.025. Epub 
      2014 Sep 19.