PMID- 25288654
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20141028
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 52
IP  - 8
DP  - 2014 Nov
TI  - Cutaneous mucormycosis and motor vehicle accidents: Findings from an Australian 
      case series.
PG  - 819-25
LID - 10.1093/mmy/myu054 [doi]
AB  - Cutaneous disease is the third most frequent manifestation of mucormycosis. The 
      clinical manifestations of and subsequent mortality due to cutaneous mucormycosis 
      are dependent on the mode of acquisition and the host immune status. Here, we 
      describe the epidemiology, clinical presentation, microbiology, and outcomes of 
      16 cutaneous mucormycosis infections managed in an Australian tertiary hospital 
      over a 15-year period. The proportion with localized (56%), deep (38%), and 
      disseminated (6%) cutaneous disease as well as the overall mortality (25%) were 
      consistent with findings reported in the published literature. Two novel forms of 
      hospital-acquired infection were reported following a sacral pressure sore and 
      insertion of a foreign body during a bone graft procedure. The majority of 
      patients were immunocompetent (75%) and/or suffered trauma (56%) with associated 
      environmental contamination. A novel finding was that motor vehicle accidents 
      (MVAs) accounted for 78% of all trauma-related cases, suggesting MVAs should 
      receive greater recognition as a potential precipitant of cutaneous mucormycosis. 
      Aggressive decontamination and debridement of devitalized tissue following trauma 
      is therefore likely to play an important role in the prevention of this rare but 
      potentially devastating infection.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of The 
      International Society for Human and Animal Mycology. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Ingram, Paul R
AU  - Ingram PR
AD  - Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, 
      Australia School of Pathology and Laboratory Medicine, University of Western 
      Australia, Perth, Australia paul.ingram@health.wa.gov.au.
FAU - Suthananthan, Arul E
AU  - Suthananthan AE
AD  - Department of General Surgery, Royal Perth Hospital, Perth, Australia.
FAU - Rajan, Ruben
AU  - Rajan R
AD  - Department of General Surgery, Royal Perth Hospital, Perth, Australia.
FAU - Pryce, Todd M
AU  - Pryce TM
AD  - Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, 
      Australia.
FAU - Sieunarine, Kishore
AU  - Sieunarine K
AD  - Department of Vascular Surgery, Royal Perth Hospital, Perth, Australia.
FAU - Gardam, Dianne J
AU  - Gardam DJ
AD  - Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, 
      Australia.
FAU - Heath, Christopher H
AU  - Heath CH
AD  - Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, 
      Australia School of Medicine and Pharmacology, University of Western Australia, 
      Perth, Australia.
LA  - eng
PT  - Journal Article
DEP - 20141006
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
SB  - IM
MH  - *Accidents, Traffic
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Australia/epidemiology
MH  - *Dermatomycoses/diagnosis/drug therapy/epidemiology/microbiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mucormycosis/diagnosis/drug therapy/epidemiology/microbiology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Australia
OT  - motor vehicle accident
OT  - mucormycosis
EDAT- 2014/10/08 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/10/08 06:00
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - myu054 [pii]
AID - 10.1093/mmy/myu054 [doi]
PST - ppublish
SO  - Med Mycol. 2014 Nov;52(8):819-25. doi: 10.1093/mmy/myu054. Epub 2014 Oct 6.