PMID- 25288805
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20211021
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 289
IP  - 46
DP  - 2014 Nov 14
TI  - Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central 
      brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) 
      signaling.
PG  - 31682-31692
LID - S0021-9258(20)33259-2 [pii]
LID - 10.1074/jbc.M114.603621 [doi]
AB  - Neuronal protein-tyrosine phosphatase 1B (PTP1B) deficiency in mice results in 
      enhanced leptin signaling and protection from diet-induced obesity; however, 
      whether additional signaling pathways in the brain contribute to the metabolic 
      effects of PTP1B deficiency remains unclear. Here, we show that the tropomyosin 
      receptor kinase B (TrkB) receptor is a direct PTP1B substrate and implicate PTP1B 
      in the regulation of the central brain-derived neurotrophic factor (BDNF) 
      signaling. PTP1B interacts with activated TrkB receptor in mouse brain and human 
      SH-SY5Y neuroblastoma cells. PTP1B overexpression reduces TrkB phosphorylation 
      and activation of downstream signaling pathways, whereas PTP1B inhibition 
      augments TrkB signaling. Notably, brains of Ptpn1(-/-) mice exhibit enhanced TrkB 
      phosphorylation, and Ptpn1(-/-) mice are hypersensitive to central BDNF-induced 
      increase in core temperature. Taken together, our findings demonstrate that PTP1B 
      is a novel physiological regulator of TrkB and that enhanced BDNF/TrkB signaling 
      may contribute to the beneficial metabolic effects of PTP1B deficiency.
CI  - (c) 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
FAU - Ozek, Ceren
AU  - Ozek C
AD  - Department of Animal Biology, School of Veterinary Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania 19104.
FAU - Kanoski, Scott E
AU  - Kanoski SE
AD  - Department of Biological Sciences, Human and Evolutionary Biology Section, 
      University of Southern California, Los Angeles, California 90089, and.
FAU - Zhang, Zhong-Yin
AU  - Zhang ZY
AD  - Department of Biochemistry and Molecular Biology, School of Medicine, Indiana 
      University, Indianapolis, Indiana 46202.
FAU - Grill, Harvey J
AU  - Grill HJ
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, Philadelphia, Pennsylvania 19104.
FAU - Bence, Kendra K
AU  - Bence KK
AD  - Department of Animal Biology, School of Veterinary Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania 19104,. Electronic address: 
      kbence@vet.upenn.edu.
LA  - eng
GR  - R01DK082417/DK/NIDDK NIH HHS/United States
GR  - R01DK021397/DK/NIDDK NIH HHS/United States
GR  - K01 DK097147/DK/NIDDK NIH HHS/United States
GR  - R01 DK021397/DK/NIDDK NIH HHS/United States
GR  - 5P30DK019525/DK/NIDDK NIH HHS/United States
GR  - R01CA69202/CA/NCI NIH HHS/United States
GR  - K01DK097147/DK/NIDDK NIH HHS/United States
GR  - R01 CA069202/CA/NCI NIH HHS/United States
GR  - R01 DK082417/DK/NIDDK NIH HHS/United States
GR  - P30 DK019525/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141006
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
RN  - EC 3.1.3.48 (PTPN1 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Line, Tumor
MH  - *Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neurons/metabolism
MH  - Phosphorylation
MH  - Protein Binding
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Receptor, trkB
MH  - Signal Transduction
MH  - Temperature
PMC - PMC4231649
OTO - NOTNLM
OT  - Brain-derived Neurotrophic Factor (BDNF)
OT  - Hypothalamus
OT  - Metabolism
OT  - Phosphotyrosine Signaling
OT  - Receptor Tyrosine Kinase
OT  - Signal Transduction
OT  - Tyrosine-Protein Phosphatase (Tyrosine Phosphatase)
EDAT- 2014/10/08 06:00
MHDA- 2015/01/21 06:00
PMCR- 2015/11/14
CRDT- 2014/10/08 06:00
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2015/11/14 00:00 [pmc-release]
AID - S0021-9258(20)33259-2 [pii]
AID - M114.603621 [pii]
AID - 10.1074/jbc.M114.603621 [doi]
PST - ppublish
SO  - J Biol Chem. 2014 Nov 14;289(46):31682-31692. doi: 10.1074/jbc.M114.603621. Epub 
      2014 Oct 6.