PMID- 25289731
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20190221
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 34
IP  - 1
DP  - 2015 Jan
TI  - Functional polymorphisms in monocyte chemoattractant protein-1 are associated 
      with increased susceptibility to ovarian cancer.
PG  - 37-42
LID - 10.1089/dna.2014.2644 [doi]
AB  - Ovarian cancer ranks fifth in cancer deaths among women, accounting for more 
      deaths than any other cancer of the female reproductive system. Monocyte 
      chemoattractant protein-1 (MCP-1) is highly expressed in various malignancies and 
      promotes carcinogenesis. The aim of the study was to investigate the association 
      between MCP-1 genetic polymorphisms and the susceptibility to ovarian cancer. 
      MCP-1 rs1024611A/G and rs3760396C/G polymorphisms were examined in 257 ovarian 
      cancer patients and 273 healthy controls. We found that distributions of 
      rs1024611GG genotype and rs3760396GG genotype were clearly increased in ovarian 
      cancer cases compared to healthy donors (odds ratio [OR]=1.93, 95% confidence 
      interval [CI]: 1.13-3.29, p=0.015; OR=3.89, 95% CI: 1.63-9.33, p=0.001). 
      Stratification analyses revealed that patients with serous papillary type had 
      further increased percentage of rs3760396GG genotype than those with other types 
      (OR=3.89, 95% CI: 1.11-13.66, p=0.024). In addition, we evaluated the possible 
      effect of MCP-1 polymorphisms on gene expression by examining the serum level of 
      MCP-1 in patients and controls. Data revealed that subjects carrying rs1024611AG 
      and GG genotypes had a significantly higher serum level of MCP-1 than those with 
      AA genotype. These data suggest that MCP-1 rs1024611A/G and rs3760396C/G 
      polymorphisms are associated with increased susceptibility to ovarian cancer, in 
      which rs1024611A/G may increase serum level of MCP-1 in the Chinese population.
FAU - Wei, Xin
AU  - Wei X
AD  - 1 Department of Gynecology, Liaocheng People's Hospital , Liaocheng, Shandong 
      Province, People's Republic of China .
FAU - Tian, Yinpu
AU  - Tian Y
FAU - Lu, Wei
AU  - Lu W
FAU - Li, Wei
AU  - Li W
FAU - Zhang, Mei
AU  - Zhang M
FAU - Lu, Xiaofen
AU  - Lu X
FAU - Liu, Yihua
AU  - Liu Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Ovarian Epithelial
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Middle Aged
MH  - Neoplasms, Glandular and Epithelial/blood/*genetics
MH  - Ovarian Neoplasms/blood/*genetics
MH  - *Polymorphism, Single Nucleotide
EDAT- 2014/10/08 06:00
MHDA- 2015/03/25 06:00
CRDT- 2014/10/08 06:00
PHST- 2014/10/08 06:00 [entrez]
PHST- 2014/10/08 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - 10.1089/dna.2014.2644 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2015 Jan;34(1):37-42. doi: 10.1089/dna.2014.2644.