PMID- 25291959
OWN - NLM
STAT- MEDLINE
DCOM- 20150127
LR  - 20161125
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 69
IP  - 12
DP  - 2014 Dec
TI  - Comparison of radiation dose and image quality from single-energy and dual-energy 
      CT examinations in the same patients screened for hepatocellular carcinoma.
PG  - e538-44
LID - S0009-9260(14)00429-2 [pii]
LID - 10.1016/j.crad.2014.08.021 [doi]
AB  - AIM: To compare radiation dose surrogates [volume CT dose index (CTDIvol), 
      dose-length product (DLP), size-specific dose estimate (SSDE), and effective 
      dose] and image noise in a cohort of patients undergoing hepatocellular carcinoma 
      screening who underwent both single-energy CT (SECT) and dual-energy CT (DECT). 
      MATERIALS AND METHODS: In this institutional review board-approved, Health 
      Insurance Portability and Accountability Act-compliant retrospective study, 74 
      adults (mean age 59.5 years) underwent 64 section SECT (120 kVp and weight-based 
      reference mAs) and 128 section dual-source DECT (100/Sn 140 kVp and CTDIvol, 
      adjusted to match the CDTIvol of the SECT protocol) on different occasions. Noise 
      levels were measured in the liver, inferior vena cava (IVC), retroperitoneal (RP) 
      fat, and aorta. Generalized linear models were constructed to compare dose and 
      noise, adjusting for effective diameter. RESULTS: The total DLP (1371.11 mGy-cm, 
      SD = 527.91) and effective dose (20.57 mSv, SD = 7.92) with SECT were 
      significantly higher than the DLP (864.84 mGy-cm, SD = 322.10) and effective dose 
      (12.97 mSv, SD = 4.83) with DECT (p < 0.001). The differences between SECT and 
      DECT increased as the patient's effective diameter increased (p < 0.001). Noise 
      levels in the liver (22.4 versus 21.9 HU), IVC (22.3 versus 23.4 HU), and RP fat 
      (23.5 versus 23 HU) were similar for DECT and SECT (p > 0.05) but were 
      significantly lower in the aorta for DECT (25.3 versus 26.4 HU; p = 0.006). 
      CONCLUSION: DECT imaging of the abdomen can achieve noise levels comparable to 
      those seen with SECT imaging without a dose penalty to patients.
CI  - Copyright (c) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Purysko, A S
AU  - Purysko AS
AD  - Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid 
      Avenue, Mail Code L10, Cleveland, OH 44195, USA. Electronic address: 
      puryska@ccf.org.
FAU - Primak, A N
AU  - Primak AN
AD  - Siemens Medical Solutions USA, Inc. 51 Valley Stream Parkway, Malvern, PA 19355, 
      USA.
FAU - Baker, M E
AU  - Baker ME
AD  - Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid 
      Avenue, Mail Code L10, Cleveland, OH 44195, USA.
FAU - Obuchowski, N A
AU  - Obuchowski NA
AD  - Quantitative Health Sciences, Imaging Institute, Cleveland Clinic, 9500 Euclid 
      Avenue, Mail Code L10, Cleveland, OH 44195, USA.
FAU - Remer, E M
AU  - Remer EM
AD  - Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid 
      Avenue, Mail Code L10, Cleveland, OH 44195, USA.
FAU - John, B
AU  - John B
AD  - Department of Gastroenterology and Hepatology, Digestive Disease Institute, 
      Cleveland Clinic, 9500 Euclid Avenue, Mail Code A51, Cleveland, OH 44195, USA.
FAU - Herts, B R
AU  - Herts BR
AD  - Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid 
      Avenue, Mail Code L10, Cleveland, OH 44195, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141005
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Burden
MH  - Carcinoma, Hepatocellular/*diagnostic imaging
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Liver Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2014/10/09 06:00
MHDA- 2015/01/28 06:00
CRDT- 2014/10/09 06:00
PHST- 2014/07/12 00:00 [received]
PHST- 2014/08/21 00:00 [revised]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2015/01/28 06:00 [medline]
AID - S0009-9260(14)00429-2 [pii]
AID - 10.1016/j.crad.2014.08.021 [doi]
PST - ppublish
SO  - Clin Radiol. 2014 Dec;69(12):e538-44. doi: 10.1016/j.crad.2014.08.021. Epub 2014 
      Oct 5.