PMID- 25292349
OWN - NLM
STAT- MEDLINE
DCOM- 20170509
LR  - 20170509
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 19
IP  - 4
DP  - 2016 Apr
TI  - Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive 
      joint damage in rheumatoid arthritis patients.
PG  - 377-84
LID - 10.1111/1756-185X.12434 [doi]
AB  - AIM: Matrix metalloproteinase-3 (MMP-3) plays a pivotal role in the destruction 
      of bone and degradation of cartilage components in rheumatoid arthritis (RA). We 
      aimed in this study to analyze the relation between baseline levels of MMP-3 and 
      the progression of joint damage in RA. METHODS: Eighty-one untreated RA patients 
      with joint symptoms for <1 year were evaluated at baseline and after 12 months as 
      regards erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), 
      rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) and plain 
      X-ray of both hands and wrists. Baseline levels of MMP-3 were measured by 
      enzyme-linked immunosorbent assay and magnetic resonance imaging (MRI) of 
      hands/wrists was performed. Disease Activity Score (DAS28) and Health Assessment 
      Questionnaire (HAQ) were performed at baseline evaluation and after 12 months. 
      RESULTS: The baseline MMP-3 levels were significantly higher in the 
      high-progression group compared with the low-progression one (95.75 +/- 42.84 vs. 
      50.45 +/- 12.83, P < 0.001). There was a positive correlation between baseline 
      levels of MMP-3 and MRI erosion score and other baseline clinical parameters, 
      except for HAQ and the van der Heijde modification of the Sharp scoring system 
      (SvdH) scores, while after 12 months, there were high positive correlations 
      between MMP-3 and SvdH score, as well as all parameters except for ESR. 
      CONCLUSION: Serum baseline levels of MMP-3 are strong prognostic markers of 
      disease activity, and act well as an early predictor of progressive joint damage 
      in recent-onset RA disease.
CI  - (c) 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing 
      Asia Pty Ltd.
FAU - Galil, Sahar Mahfouz Abdel
AU  - Galil SM
AD  - Department of Rheumatology & Rehabilitation, Faculty of Medicine, Zagazig 
      University, Zagazig, Egypt.
AD  - Department of Medicine Department, Faculty of Medicine, Umm Al-Qura University, 
      Holly Markkah, Saudi Arabia.
FAU - El-Shafey, Abeer Mohamed
AU  - El-Shafey AM
AD  - Department of Rheumatology & Rehabilitation, Faculty of Medicine, Zagazig 
      University, Zagazig, Egypt.
FAU - Hagrass, Hoda A
AU  - Hagrass HA
AD  - Department of Clinical Pathology, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt.
FAU - Fawzy, Faten
AU  - Fawzy F
AD  - Department of Radiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
FAU - Sammak, Ahmed El
AU  - Sammak AE
AD  - Department of Radiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20141007
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
CIN - Int J Rheum Dis. 2017 Nov;20(11):1794. PMID: 25900012
MH  - Adult
MH  - Arthritis, Rheumatoid/blood/diagnosis/enzymology/pathology
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Health Status Indicators
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Joints/*enzymology/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Up-Regulation
OTO - NOTNLM
OT  - matrix metalloproteinase-3
OT  - prognostic marker
OT  - rheumatoid arthritis
EDAT- 2014/10/09 06:00
MHDA- 2017/05/10 06:00
CRDT- 2014/10/09 06:00
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2017/05/10 06:00 [medline]
AID - 10.1111/1756-185X.12434 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2016 Apr;19(4):377-84. doi: 10.1111/1756-185X.12434. Epub 2014 
      Oct 7.