PMID- 25293510
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 14
IP  - 11
DP  - 2014 Nov
TI  - Comprehensive bio-imaging using myocardial perfusion reserve index during cardiac 
      magnetic resonance imaging and high-sensitive troponin T for the prediction of 
      outcomes in heart transplant recipients.
PG  - 2607-16
LID - 10.1111/ajt.12924 [doi]
AB  - We sought to determine the ability of quantitative myocardial perfusion reserve 
      index (MPRI) by cardiac magnetic resonance (CMR) and high-sensitive troponin T 
      (hsTnT) for the prediction of cardiac allograft vasculopathy (CAV) and cardiac 
      outcomes in heart transplant (HT) recipients. In 108 consecutive HT recipients 
      (organ age 4.1+/-4.7 years, 25 [23%] with diabetes mellitus) who underwent cardiac 
      catheterization, CAV grade by International Society for Heart & Lung 
      Transplantation (ISHLT) criteria, MPRI, late gadolinium enhancement (LGE) and 
      hsTnT values were obtained. Outcome data including cardiac death and urgent 
      revascularization ("hard cardiac events") and revascularization procedures were 
      prospectively collected. During a follow-up duration of 4.2+/-1.4 years, seven 
      patients experienced hard cardiac events and 11 patients underwent elective 
      revascularization procedures. By multivariable analysis, hsTnT and MPRI both 
      independently predicted cardiac events, surpassing the value of LGE and CAV by 
      ISHLT criteria. Furthermore, hsTnT and MPRI provided complementary value. Thus, 
      patients with high hsTnT and low MPRI showed the highest rates of cardiac events 
      (annual event rate=14.5%), while those with low hsTnT and high MPRI exhibited 
      excellent outcomes (annual event rate=0%). In conclusion, comprehensive 
      "bio-imaging" using hsTnT, as a marker of myocardial microinjury, and CMR, as a 
      marker of microvascular integrity and myocardial damage by LGE, may aid 
      personalized risk-stratification in HT recipients.
CI  - (c) Copyright 2014 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Hofmann, N P
AU  - Hofmann NP
AD  - Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
FAU - Steuer, C
AU  - Steuer C
FAU - Voss, A
AU  - Voss A
FAU - Erbel, C
AU  - Erbel C
FAU - Celik, S
AU  - Celik S
FAU - Doesch, A
AU  - Doesch A
FAU - Ehlermann, P
AU  - Ehlermann P
FAU - Giannitsis, E
AU  - Giannitsis E
FAU - Buss, S J
AU  - Buss SJ
FAU - Katus, H A
AU  - Katus HA
FAU - Korosoglou, G
AU  - Korosoglou G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Biomarkers)
RN  - 0 (Troponin T)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Coronary Vessels/*pathology
MH  - Female
MH  - *Heart Transplantation
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Troponin T/*blood
OTO - NOTNLM
OT  - Biomarker
OT  - cardiovascular disease
OT  - clinical research/practice
OT  - heart transplantation/cardiology
EDAT- 2014/10/09 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/10/09 06:00
PHST- 2014/03/11 00:00 [received]
PHST- 2014/06/11 00:00 [revised]
PHST- 2014/06/29 00:00 [accepted]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - S1600-6135(22)25669-X [pii]
AID - 10.1111/ajt.12924 [doi]
PST - ppublish
SO  - Am J Transplant. 2014 Nov;14(11):2607-16. doi: 10.1111/ajt.12924. Epub 2014 Oct 
      7.