PMID- 25293818
OWN - NLM
STAT- MEDLINE
DCOM- 20150423
LR  - 20170901
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 83
IP  - 12
DP  - 2014 Dec
TI  - Ultra low-dose of gadobenate dimeglumine for late gadolinium enhancement (LGE) 
      imaging in acute myocardial infarction: a feasibility study.
PG  - 2151-2158
LID - S0720-048X(14)00430-6 [pii]
LID - 10.1016/j.ejrad.2014.09.002 [doi]
AB  - PURPOSE: To assess the feasibility of using an ultra-low dose (0.05 mmol/kg of 
      body weight [BW]) of high relaxivity contrast agent for late gadolinium 
      enhancement (LGE) imaging in patients with acute myocardial infarction (AMI). 
      MATERIALS AND METHODS: 17 consecutive patients (mean age, 60.1 +/- 10.3 years) with 
      ST-segment elevation AMI underwent two randomized cardiac magnetic resonance 
      studies (exam intervals between 24 and 48h) on a 1.5T unit during the first week 
      after the event using gadobenate dimeglumine (Gd-BOPTA) at the dose of 0.1 
      mmol/kg BW (standard dose or SD group) and 0.05 mmol/kg BW (half dose or HD 
      group). Image quality was qualitatively assessed. Quantitative analysis of LGE 
      were performed by measuring signal intensity (SI), signal-to-noise ratio (SNR) in 
      the infarcted myocardium (IM), non-infarcted myocardium (N-IM) and left 
      ventricular cavity (LVC) in images acquired at 1, 3, 5, 10, 15 and 20 min after 
      administration of Gd-BOPTA using both contrast media protocol. Contrast-to-noise 
      ratio (CNR) between IM and N-IM (CNR IM/N-IM) and between IM and LVC (CNR IM/LVC) 
      were also quantified for each time point. Moreover the extent of infarcted 
      myocardium was measured. RESULTS: 102 LGE images were evaluated for each dose 
      group. Quality score was significantly higher for SD at 1, 15 and 20 min 
      (0.002<p<0.046) and for HD at 5 min (p=0.013). SNR has been higher in the SD 
      group compared to the HD group even though not statistically significant at any 
      time-point for both IM (SD vs. HD: 87.7 +/- 73 vs. 65 +/- 66; 0.15<p<0.38) and N-IM 
      (SD vs. HD: 22 +/- 61 vs. 9.9 +/- 6.5; 0.09<p<0.43). LVC SNR was significantly higher 
      with SD at 10 min (p=0.03), 15 min (p=0.001) and 20 min (p=0.004). CNR between 
      the IM and N-IM was significantly higher using SD compared to HD (1382.24 +/- 1049 
      vs. 695.4 +/- 500; 0.000<p<0.028) at 10, 15 and 20 min. No significant differences 
      in CNR IM/LVC were noted for HD acquired 5 min after CM administration compared 
      to SD acquired at 10 (p=0.34), 15 (p=0.96) and 20 (p=0.41) min, and between HD at 
      10 min compared to SD acquired at 15 min (p=0.78) and 20 min (p=0.32). Good 
      correlation between SD and HD (0.56<r(2)<0.85, p<0.024) was found at all 
      time-points in the measuring of IA. CONCLUSION: The use of a 0.05 mmol/kg dose of 
      gadobenate dimeglumine is feasible for LGE imaging of acute MI and the best image 
      quality is obtained at 5 min after contrast administration. It could be 
      beneficial in patient with renal failure and a solution to improve the 
      identification of subendocardial infarction reducing examination time, costs and 
      total gadolinium load. However, the standard dose of 0.1 mmol/kg provides overall 
      better image quality, with the best performance obtained at the delay of 10 min 
      or more after Gd-BOPTA administration, and it should be routinely preferred.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Galea, Nicola
AU  - Galea N
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: nicola.galea@uniroma1.it.
FAU - Francone, Marco
AU  - Francone M
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: marco.francone@uniroma1.it.
FAU - Zaccagna, Fulvio
AU  - Zaccagna F
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: f.zaccagna@gmail.com.
FAU - Ciolina, Federica
AU  - Ciolina F
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: federica.ciolina@gmail.com.
FAU - Cannata, David
AU  - Cannata D
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: davidrum@yahoo.it.
FAU - Algeri, Emanuela
AU  - Algeri E
AD  - Service de Radiologie et Imagerie Cardiovasculaire, Hopital Cardiologique, Centre 
      Hospitalier Regional et Universitaire de Lille, Avenue Oscar Lambret, 59037 Lille 
      Cedex, France. Electronic address: emanuela_algeri@yahoo.com.
FAU - Agati, Luciano
AU  - Agati L
AD  - Department of Cardiovascular, Respiratory, Nephrologic, Anestesiologic and 
      Geriatric Sciences, Sapienza University of Rome, Policlinico Umberto I, Via del 
      Policlinico 165, 00161 Rome, Rome, Italy. Electronic address: 
      luciano.agati@uniroma1.it.
FAU - Catalano, Carlo
AU  - Catalano C
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: carlo.catalano@uniroma1.it.
FAU - Carbone, Iacopo
AU  - Carbone I
AD  - Department of Radiological Sciences, Pathology and Oncology, Policlinico Umberto 
      I, "Sapienza" University of Rome, Viale Regina Elena 315, 00161 Rome, Italy. 
      Electronic address: iacopo.carbone@uniroma1.it.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140928
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Aged
MH  - *Contrast Media
MH  - Dose-Response Relationship, Drug
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Image Enhancement
MH  - Male
MH  - Meglumine/*analogs & derivatives
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - *Organometallic Compounds
OTO - NOTNLM
OT  - Anterior wall myocardial infarction
OT  - Cardiac imaging techniques
OT  - Gd-BOPTA
OT  - Image quality enhancement
OT  - Magnetic resonance imaging
EDAT- 2014/10/09 06:00
MHDA- 2015/04/24 06:00
CRDT- 2014/10/09 06:00
PHST- 2014/04/28 00:00 [received]
PHST- 2014/07/08 00:00 [revised]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2015/04/24 06:00 [medline]
AID - S0720-048X(14)00430-6 [pii]
AID - 10.1016/j.ejrad.2014.09.002 [doi]
PST - ppublish
SO  - Eur J Radiol. 2014 Dec;83(12):2151-2158. doi: 10.1016/j.ejrad.2014.09.002. Epub 
      2014 Sep 28.