PMID- 25293868
OWN - NLM
STAT- MEDLINE
DCOM- 20160902
LR  - 20211021
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Print)
IS  - 1399-543X (Linking)
VI  - 16
IP  - 8
DP  - 2015 Dec
TI  - Elevated plasma pigment epithelium-derived factor in children with type 2 
      diabetes mellitus is attributable to obesity.
PG  - 600-5
LID - 10.1111/pedi.12226 [doi]
AB  - BACKGROUND: Pigment epithelium-derived factor (PEDF) is a member of the serpin 
      family secreted by adipocytes. Plasma PEDF is increased in obese children and 
      adults. Adults with type 2 diabetes mellitus (T2DM) have higher circulating PEDF 
      but there are no reports in children with T2DM. OBJECTIVE: To compare PEDF 
      concentration in children with T2DM to normal weight and obese children without 
      T2DM and determine associations with anthropometric or serum factors. METHODS: 
      Participants were 34 obese children with T2DM diagnosed by American Diabetes 
      Association (ADA) criteria, 61 normal weight [body mass index (BMI) 25-75 
      percentile] and 63 obese (BMI >/= 95 percentile) children of age 8-18 yr. Plasma 
      PEDF was measured in fasting plasma samples. Anthropometric, serum, and body 
      composition (dual-energy x-ray absorptiometry, DXA) data were obtained for each 
      subject to identify potential predictor variables. RESULTS: PEDF was 55% higher 
      (p = 0.001) in the T2DM group compared with normal weight children, but did not 
      differ from obese children. In the T2DM group, fat mass and lean mass both 
      individually predicted PEDF (r(2) = 0.22 and 0.17, p = 0.02 and p < 0.01, 
      respectively). PEDF was positively correlated with homeostatic model assessment - 
      insulin resistance (HOMA-IR) when all groups were combined (r(2) = 0.15, p<0.001). 
      CONCLUSIONS: Plasma PEDF was similar in the T2DM and obese groups, therefore, 
      obesity, rather than diabetes, may account for the higher PEDF in children with 
      T2DM compared with normal weight children. PEDF was positively associated with 
      both lean mass and fat mass both of which may contribute to the circulating level 
      of the protein, and potentially to PEDF's association with insulin resistance in 
      obese children with and without diabetes.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Tryggestad, Jeanie B
AU  - Tryggestad JB
AD  - Department of Pediatrics, Section of Diabetes/Endocrinology, University of 
      Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
FAU - Wang, Joshua J
AU  - Wang JJ
AD  - Department of Ophthalmology, School of Medicine and Biomedical Sciences, 
      University at Buffalo, The State University of New York, Buffalo, NY, USA.
AD  - Department of Biochemistry, School of Medicine and Biomedical Sciences, 
      University at Buffalo, The State University of New York, Buffalo, NY, USA.
FAU - Zhang, Sarah X
AU  - Zhang SX
AD  - Department of Ophthalmology, School of Medicine and Biomedical Sciences, 
      University at Buffalo, The State University of New York, Buffalo, NY, USA.
AD  - Department of Biochemistry, School of Medicine and Biomedical Sciences, 
      University at Buffalo, The State University of New York, Buffalo, NY, USA.
FAU - Thompson, David M
AU  - Thompson DM
AD  - Department of Biostatistics and Epidemiology, University of Oklahoma Health 
      Sciences Center, Oklahoma City, OK, USA.
FAU - Short, Kevin R
AU  - Short KR
AD  - Department of Pediatrics, Section of Diabetes/Endocrinology, University of 
      Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
LA  - eng
GR  - P20 RR024215/RR/NCRR NIH HHS/United States
GR  - P20 RR 024215/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20141008
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Eye Proteins)
RN  - 0 (Lipids)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (pigment epithelium-derived factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Body Composition
MH  - C-Reactive Protein/metabolism
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Eye Proteins/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Nerve Growth Factors/*blood
MH  - Obesity/*blood/*complications
MH  - Serpins/*blood
PMC - PMC8327465
MID - NIHMS1727664
OTO - NOTNLM
OT  - PEDF
OT  - T2DM
OT  - obesity
EDAT- 2014/10/09 06:00
MHDA- 2016/09/03 06:00
PMCR- 2021/08/02
CRDT- 2014/10/09 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/08/13 00:00 [revised]
PHST- 2014/09/10 00:00 [accepted]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2016/09/03 06:00 [medline]
PHST- 2021/08/02 00:00 [pmc-release]
AID - 10.1111/pedi.12226 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2015 Dec;16(8):600-5. doi: 10.1111/pedi.12226. Epub 2014 Oct 8.