PMID- 25295485
OWN - NLM
STAT- MEDLINE
DCOM- 20160503
LR  - 20211021
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Print)
IS  - 2192-2640 (Linking)
VI  - 4
IP  - 3
DP  - 2015 Feb 18
TI  - N-trimethylchitosan/alginate layer-by-layer self assembly coatings act as "fungal 
      repellents" to prevent biofilm formation on healthcare materials.
PG  - 469-75
LID - 10.1002/adhm.201400428 [doi]
AB  - Fungal biofilm formation on healthcare materials is a significant clinical 
      concern, often leading to medical-device-related infections, which are difficult 
      to treat. A novel fungal repellent strategy is developed to control fungal 
      biofilm formation. Methylacrylic acid (MAA) is grated onto poly methyl 
      methacrylate (PMMA)-based biomaterials via plasma-initiated grafting 
      polymerization. A cationic polymer, trimethylchitosan (TMC), is synthesized by 
      reacting chitosan with methyl iodide. Sodium alginate (SA) is used as an anionic 
      polymer. TMC/SA multilayers are coated onto the MAA-grafted PMMA via 
      layer-by-layer self-assembly. The TMC/SA multilayer coatings significantly reduce 
      fungal initial adhesion, and effectively prevent fungal biofilm formation. It is 
      concluded that the anti-adhesive property of the surface is due to its 
      hydrophilicity, and that the biofilm-inhibiting action is attributed to the 
      antifungal activity of TMC as well as the chelating function of TMC and SA, which 
      may have acted as fungal repellents. Phosphate buffered saline (PBS)-immersion 
      tests show that the biofilm-modulating effect of the multilayer coatings is 
      stable for more than 4 weeks. Furthermore, the presence of TMC/SA multilayer 
      coatings improves the biocompatibility of the original PMMA, offering a simple, 
      yet effective, strategy for controlling fungal biofilm formation.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Jiang, Fuguang
AU  - Jiang F
AD  - Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
FAU - Yeh, Chih-Ko
AU  - Yeh CK
FAU - Wen, Jianchuan
AU  - Wen J
FAU - Sun, Yuyu
AU  - Sun Y
LA  - eng
GR  - I01 BX001103/BX/BLRD VA/United States
GR  - R01 DE021084/DE/NIDCR NIH HHS/United States
GR  - R03 DE018735/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20141008
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Alginates)
RN  - 0 (Antifungal Agents)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Hexuronic Acids)
RN  - 0 (N-trimethyl chitosan chloride)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Alginates/chemistry/*pharmacology
MH  - Antifungal Agents/chemistry/*pharmacology
MH  - Biofilms/drug effects
MH  - Candida albicans/*drug effects/physiology
MH  - Chitosan/chemistry/*pharmacology
MH  - Coated Materials, Biocompatible/*chemistry/pharmacology
MH  - Glucuronic Acid/chemistry/pharmacology
MH  - Hexuronic Acids/chemistry/pharmacology
MH  - Polymethyl Methacrylate/chemistry
PMC - PMC4425286
MID - NIHMS679338
OTO - NOTNLM
OT  - alginate
OT  - fungal biofilms
OT  - layer-by-layer coatings
OT  - trimethylchitosan
EDAT- 2014/10/09 06:00
MHDA- 2016/05/04 06:00
PMCR- 2016/02/18
CRDT- 2014/10/09 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/08/28 00:00 [revised]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2016/05/04 06:00 [medline]
PHST- 2016/02/18 00:00 [pmc-release]
AID - 10.1002/adhm.201400428 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2015 Feb 18;4(3):469-75. doi: 10.1002/adhm.201400428. Epub 
      2014 Oct 8.