PMID- 25296364
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 47
IP  - 11
DP  - 2014 Nov
TI  - Relationship between deep venous thrombosis and inflammatory cytokines in 
      postoperative patients with malignant abdominal tumors.
PG  - 1003-7
LID - S0100-879X2014001101003 [pii]
AB  - Deep venous thrombosis (DVT) is a common surgical complication in cancer patients 
      and evidence that inflammation plays a role in the occurrence of DVT is 
      increasing. We studied a population of cancer patients with abdominal 
      malignancies with the aim of investigating whether the levels of circulating 
      inflammatory cytokines were associated with postoperative DVT, and to determine 
      the levels in DVT diagnoses. The serum levels of C-reactive protein (CRP), 
      interleukins (IL)-6 and IL-10, nuclear transcription factor-kappaB (NF-kappaB) and 
      E-selectin (E-Sel) were determined in 120 individuals, who were divided into 3 
      groups: healthy controls, patients with and patients without DVT after surgery 
      for an abdominal malignancy. Data were analyzed by ANOVA, Dunnet's T3 test, 
      chi-square test, and univariate and multivariate logistic regression as needed. 
      The CRP, IL-6, NF-kappaB, and E-Sel levels in patients with DVT were significantly 
      higher than those in the other groups (P<0.05). The IL-10 level was higher in 
      patients with DVT than in controls but lower than in patients without DVT. 
      Univariate analysis revealed that CRP, IL-6, NF-kappaB, and E-Sel were statistically 
      associated with the risk of DVT (OR=1.98, P=0.002; OR=1.17, P=0.000; OR=1.03, 
      P=0.042; and OR=1.38, P=0.003; respectively), whereas IL-10 had a protective 
      effect (OR=0.94, P=0.011). Multivariate analysis showed that E-Sel was an 
      independent risk factor (OR=1.41, P=0.000). Thus, this study indicated that an 
      increased serum level of E-Sel was associated with increased DVT risk in 
      postoperative patients with abdominal malignancy, indicating that E-Sel may be a 
      useful predictor of diagnosis of DVT.
FAU - Du, T
AU  - Du T
AD  - Department of General Surgery, Zhongnan Hospital, School of Medicine, National 
      Wuhan University, Wuhan, Hubei Province, China.
FAU - Tan, Z
AU  - Tan Z
AD  - Department of General Surgery, Zhongnan Hospital, School of Medicine, National 
      Wuhan University, Wuhan, Hubei Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140822
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Cytokines)
RN  - 0 (E-Selectin)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 130068-27-8 (Interleukin-10)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Abdominal Neoplasms/blood/*surgery
MH  - Adult
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - E-Selectin/blood
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/blood
MH  - Postoperative Period
MH  - Risk Assessment
MH  - Risk Factors
MH  - Venous Thrombosis/*etiology
PMC - PMC4230292
EDAT- 2014/10/09 06:00
MHDA- 2015/07/03 06:00
PMCR- 2014/08/22
CRDT- 2014/10/09 06:00
PHST- 2013/12/09 00:00 [received]
PHST- 2014/06/13 00:00 [accepted]
PHST- 2014/10/09 06:00 [entrez]
PHST- 2014/10/09 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PHST- 2014/08/22 00:00 [pmc-release]
AID - S0100-879X2014001101003 [pii]
AID - 10.1590/1414-431X20143695 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2014 Nov;47(11):1003-7. doi: 10.1590/1414-431X20143695. Epub 
      2014 Aug 22.