PMID- 25297661
OWN - NLM
STAT- MEDLINE
DCOM- 20160805
LR  - 20221207
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 21
IP  - 2
DP  - 2015 Feb
TI  - Diabetes Status and Race are Associated with Cardiovascular Risk Markers in Obese 
      Adolescents.
PG  - 165-73
LID - 10.4158/EP14087.OR [doi]
AB  - OBJECTIVE: The objective of this study was to evaluate differences in 
      cardiovascular disease (CVD) risk markers in obese adolescents based on diabetes 
      status and race in order to improve risk-reduction intervention strategies. 
      METHODS: This was a retrospective, cross-sectional study of obese adolescents, 
      age 10 to 21 years, who were evaluated at Children's of Alabama between 2000 and 
      2012. Subjects were classified by glycated hemoglobin (HbA1c) as having 
      normoglycemia, prediabetes, or type 2 diabetes mellitus (T2DM). RESULTS: There 
      were a total of 491 African American (AA) or Caucasian American (CA) subjects. 
      Body mass index was not different between HbA1c and racial groups. Compared to 
      subjects with normoglycemia or prediabetes, subjects with T2DM had higher levels 
      of total cholesterol (TC) (178.6 +/- 43.8 mg/dL vs. 161.5 +/- 32.5 mg/dL vs. 162.4 +/- 
      30.6 mg/dL; P<.0001) and low-density-lipoprotein cholesterol (107.4 +/- 39.2 mg/dL 
      vs. 97.0 +/- 31.0 mg/dL vs. 97.5 +/- 26.9 mg/dL; P = .0073). Compared with AA 
      subjects, CA subjects had lower high-density-lipoprotein cholesterol (HDL-C) 
      levels (40.4 +/- 10.4 mg/dL vs. 44.3 +/- 11.9 mg/dL; P = .0005) and higher non-HDL-C 
      levels (129.6 +/- 36.2 mg/dL vs. 122.5 +/- 37.5 mg/dL; P = .0490). Of the 
      characteristics studied, HbA1c had the most significant positive association with 
      dyslipidemia and was strongly correlated with both TC (beta, 4.21; P<.0001) and 
      non-HDL-C (beta, 4.3; P<.0001). CONCLUSION: Obese adolescents with T2DM have more 
      abnormal lipoprotein profiles than those with normoglycemia or prediabetes. Obese 
      CA adolescents have more abnormal lipids than obese AA adolescents. HbA1c was the 
      characteristic most highly associated with abnormal lipoprotein profiles in our 
      subjects. Our results show that CVD risk markers in obese adolescents vary by 
      race and HbA1c concentration.
FAU - Colvin, Caroline W
AU  - Colvin CW
AD  - Division of Pediatric Endocrinology, Department of Pediatrics, University of 
      Alabama School of Medicine, Birmingham, Alabama.
FAU - Ashraf, Ambika P
AU  - Ashraf AP
AD  - Division of Pediatric Endocrinology, Department of Pediatrics, University of 
      Alabama School of Medicine, Birmingham, Alabama.
FAU - Griffin, Russell L
AU  - Griffin RL
AD  - Department of Epidemiology, School of Public Health, University of Alabama at 
      Birmingham, Birmingham, Alabama.
FAU - Diaz, Benjamin Tuanama
AU  - Diaz BT
AD  - Division of Pediatric Surgery, Department of Surgery, University of Alabama 
      School of Medicine, Birmingham, Alabama.
FAU - Yannam, Govardhana Rao
AU  - Yannam GR
AD  - Division of Pediatric Surgery, Department of Surgery, University of Alabama 
      School of Medicine, Birmingham, Alabama.
FAU - Johnson, Joffre E
AU  - Johnson JE
AD  - University of Alabama School of Medicine, Birmingham, Alabama.
FAU - Lucas, Alan P
AU  - Lucas AP
AD  - University of Alabama School of Medicine, Birmingham, Alabama.
FAU - Propst, Matthew
AU  - Propst M
AD  - Ross University School of Medicine, Dominica, West Indies.
FAU - Harmon, Carroll M
AU  - Harmon CM
AD  - Division of Pediatric Surgery, Department of Surgery, University of Alabama 
      School of Medicine, Birmingham, Alabama.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - Endocr Pract. 2015 Feb;21(2):208-10. PMID: 25711687
MH  - Adolescent
MH  - Black or African American
MH  - Cardiovascular Diseases/*etiology
MH  - Child
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Obesity/*complications/ethnology
MH  - Retrospective Studies
MH  - White People
MH  - Young Adult
EDAT- 2014/10/10 06:00
MHDA- 2016/08/06 06:00
CRDT- 2014/10/10 06:00
PHST- 2014/10/10 06:00 [entrez]
PHST- 2014/10/10 06:00 [pubmed]
PHST- 2016/08/06 06:00 [medline]
AID - S1530-891X(20)35759-1 [pii]
AID - 10.4158/EP14087.OR [doi]
PST - ppublish
SO  - Endocr Pract. 2015 Feb;21(2):165-73. doi: 10.4158/EP14087.OR.