PMID- 25297916
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 14
DP  - 2014 Oct 9
TI  - Resting heart rate as a marker for identifying the risk of undiagnosed type 2 
      diabetes mellitus: a cross-sectional survey.
PG  - 1052
LID - 10.1186/1471-2458-14-1052 [doi]
LID - 1052
AB  - BACKGROUND: Fast resting heart rate might increase the risk of developing type 2 
      diabetes mellitus (T2DM). However, it is unclear whether resting heart rate could 
      be used to predict the risk of undiagnosed T2DM. Therefore, the purposes of this 
      study were to examine the association between resting heart rate and undiagnosed 
      T2DM, and evaluate the feasibility of using resting heart rate as a marker for 
      identifying the risk of undiagnosed T2DM. METHODS: A cross-sectional survey was 
      conducted. Resting heart rate and relevant covariates were collected and 
      measured. Fasting blood samples were obtained to measure blood glucose using the 
      modified hexokinase enzymatic method. Predictive performance was analyzed by 
      Receiver Operating Characteristic (ROC) curve. RESULTS: This study included 16, 
      636 subjects from rural communities aged 35-78 years. Resting heart rate was 
      significantly associated with undiagnosed T2DM in both genders. For resting heart 
      rate categories of <60, 60-69, 70-79, and >/=80 beats/min, adjusted odds ratios for 
      undiagnosed T2DM were 1.04, 2.32, 3.66 and 1.05, 1.57, 2.98 in male and female 
      subjects, respectively. For male subjects, resting heart rate >/=70 beats/min could 
      predict undiagnosed T2DM with 76.56% sensitivity and 48.64% specificity. For 
      female subjects, the optimum cut-off point was >/=79 beats/min with 49.72% 
      sensitivity and 67.53% specificity. The area under the ROC curve for predicting 
      undiagnosed T2DM was 0.65 (95% CI: 0.64-0.66) and 0.61(95% CI: 0.60-0.62) in male 
      and female subjects, respectively. CONCLUSIONS: Fast resting heart rate is 
      associated with an increased risk of undiagnosed T2DM in male and female 
      subjects. However, resting heart rate as a marker has limited potential for 
      screening those at high risk of undiagnosed T2DM in adults living in rural areas.
FAU - Li, Yu-qian
AU  - Li YQ
FAU - Sun, Chang-qing
AU  - Sun CQ
FAU - Li, Lin-lin
AU  - Li LL
FAU - Wang, Ling
AU  - Wang L
FAU - Guo, Yi-rui
AU  - Guo YR
FAU - You, Ai-guo
AU  - You AG
FAU - Xi, Yuan-lin
AU  - Xi YL
FAU - Wang, Chong-jian
AU  - Wang CJ
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, 100 Kexue Avenue, Zhengzhou 450001, Henan, PR China. 
      tjwcj2005@126.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141009
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers
MH  - Blood Glucose/analysis/metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis/physiopathology
MH  - Fasting
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - *Mass Screening
MH  - Middle Aged
MH  - Odds Ratio
MH  - ROC Curve
MH  - Reference Values
MH  - Risk
MH  - Rural Population
MH  - Sensitivity and Specificity
PMC - PMC4210587
EDAT- 2014/10/10 06:00
MHDA- 2015/09/01 06:00
PMCR- 2014/10/09
CRDT- 2014/10/10 06:00
PHST- 2013/03/21 00:00 [received]
PHST- 2014/08/18 00:00 [accepted]
PHST- 2014/10/10 06:00 [entrez]
PHST- 2014/10/10 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
PHST- 2014/10/09 00:00 [pmc-release]
AID - 1471-2458-14-1052 [pii]
AID - 7176 [pii]
AID - 10.1186/1471-2458-14-1052 [doi]
PST - epublish
SO  - BMC Public Health. 2014 Oct 9;14:1052. doi: 10.1186/1471-2458-14-1052.