PMID- 25298957 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141009 LR - 20211021 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 13 IP - 1 DP - 2014 TI - Liquid base cytology in evaluation of thyroid nodules. PG - 82 LID - 10.1186/s40200-014-0082-5 [doi] LID - 82 AB - BACKGROUND: Palpable thyroid nodules are present in 4-7% of general population and Fine Needle Aspiration (FNA) is now accepted by endocrinologists and thyroid surgeons as a safe, simple and cost effective procedure for evaluating a thyroid nodule. The obtained sample can be spread directly on slides, processed as cell block preparations or prepared as liquid base smears. Liquid base method has been recently accepted due to its shorter preparation time and better preservation of nuclear details. The aim of this study is to compare the diagnostic results of two commonly used methods: Liquid Base Preparation and Cell Block Preparation in evaluation of thyroid nodules. METHODS: The samples were taken from 100 patients with a solitary nodule or a prominent nodule on a multinodular goiter background (excluding hot nodules). The obtained samples were used to prepare conventional smears (CS), Cell Block Preparations (CBP) and Liquid Base Preparations (LBP). The slides were studied by two pathologists, considering the following parameters: Cellularity, Colloid, Lymphocytes/Plasma cells and Macrophages. RESULTS: 87% of cases revealed informative results in LBP method while in the same group of patients only 69% of samples were informative after processing by CBP method. Sensitivity and specificity of both methods compared with the conventional smears and with each other and it is concluded that LBP is a reliable method for evaluating of a thyroid nodule. Other studies also show the same results. CONCLUSION: The liquid base method should be trusted due to its easier procedure, cleaner slide background, its higher specificity and higher diagnostic yields. It can be used instead of CBP and in association with CS to increase the accuracy of evaluation of thyroid nodules. FAU - Keyhani, Elahe AU - Keyhani E AD - Genetics Research Center-University of Social Welfare and Rehabilitation Sciences, Koudakyar st.-Daneshjoo blv., Tehran, (1985713834) Iran. FAU - Sharghi, Sasan A AU - Sharghi SA AD - Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, (1411413137) Iran. FAU - Amini, Rana AU - Amini R AD - Sepid Pathobiology Laboratory, No.831-North Taleghani Blv., Karaj, (3155783618) Iran. FAU - Sharghi, Sina A AU - Sharghi SA AD - Iran University of Medical Sciences-Hemmat Highway, Tehran, (1449614535) Iran. FAU - Karimlou, Masoud AU - Karimlou M AD - Social Department of Health Research Center, Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, (1985713834) Iran. FAU - Moghaddam, Fatemeh A AU - Moghaddam FA AD - Genetics Research Center-University of Social Welfare and Rehabilitation Sciences, Koudakyar st.-Daneshjoo blv., Tehran, (1985713834) Iran. FAU - Larijani, Bagher AU - Larijani B AD - Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, (1411413137) Iran. LA - eng PT - Journal Article DEP - 20140910 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC4189558 OTO - NOTNLM OT - Cell block preparation OT - Conventional smears OT - Liquid base preparation OT - Thyroid fine needle aspiration EDAT- 2014/10/10 06:00 MHDA- 2014/10/10 06:01 PMCR- 2014/09/10 CRDT- 2014/10/10 06:00 PHST- 2014/02/16 00:00 [received] PHST- 2014/07/15 00:00 [accepted] PHST- 2014/10/10 06:00 [entrez] PHST- 2014/10/10 06:00 [pubmed] PHST- 2014/10/10 06:01 [medline] PHST- 2014/09/10 00:00 [pmc-release] AID - 82 [pii] AID - 10.1186/s40200-014-0082-5 [doi] PST - epublish SO - J Diabetes Metab Disord. 2014 Sep 10;13(1):82. doi: 10.1186/s40200-014-0082-5. eCollection 2014.