PMID- 25299501
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20150629
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 22
IP  - 3
DP  - 2015
TI  - Adjunctive mild hypothermia therapy to primary percutaneous coronary intervention 
      in patients with ST segment elevation myocardial infarction complicated with 
      cardiogenic shock: A pilot feasibility study.
PG  - 285-9
LID - 10.5603/CJ.a2014.0068 [doi]
AB  - BACKGROUND: Despite successful primary reperfusion therapy, patients may develop 
      large myocardial infarction related in part to reperfusion injury. Induction of 
      mild therapeutic hypothermia (TH) applied in patients has demonstrated beneficial 
      effect in reducing reperfusion injury. The aim of the study was to evaluate the 
      feasibility and safety of adjunctive mild TH to primary percutaneous coronary 
      intervention (PPCI) in patients with acute ST elevation myocardial infarction 
      (STEMI) complicated with cardiogenic shock (CS). METHODS: We conducted a 
      prospective single center, open label, historical control study. Patients 
      presenting with STEMI and CS despite maximal support therapy scheduled for PPCI 
      were included. Death was defined as primary endpoint. Secondary outcomes 
      included: TH adverse effect--such as fever, refractory hypotension and 
      arrhythmias, infarct size measured by area under the curve of biomarkers. 
      RESULTS: Eight consecutive patients were prospectively enrolled (TH group). 
      Thirteen clinically similar patients identified from our database, admitted over 
      2 years, comprised the historical control group (control group). In the 
      hypothermia group, the mortality was 50% compared with 46% in the control group. 
      There was no difference in the secondary outcomes. CONCLUSIONS: TH as adjunctive 
      therapy in STEMI patients complicated with CS is feasible and safe. Based on 
      these preliminary observations there appears to be no significant clinical 
      advantage to this form of therapy.
FAU - Blatt, Alex
AU  - Blatt A
AD  - Cardiology Department, Assaf Harofeh, Medical Center, Tel Aviv University Tel 
      Aviv. alexb@asaf.health.gov.il.
FAU - Elbaz-Greener, Gabby Atalya
AU  - Elbaz-Greener GA
FAU - Mizrachi, Avi
AU  - Mizrachi A
FAU - J'bara, Ziad
AU  - J'bara Z
FAU - Taraboulos, Tali
AU  - Taraboulos T
FAU - Litovchik, Ilia
AU  - Litovchik I
FAU - Vered, Zvi
AU  - Vered Z
FAU - Minha, Sa'ar
AU  - Minha S
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20141009
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
MH  - Aged
MH  - Combined Modality Therapy
MH  - Feasibility Studies
MH  - Female
MH  - Historically Controlled Study
MH  - Humans
MH  - *Hypothermia, Induced/adverse effects
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/diagnosis/mortality/*therapy
MH  - *Percutaneous Coronary Intervention/adverse effects/mortality
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Risk Factors
MH  - Shock, Cardiogenic/diagnosis/etiology/mortality/*therapy
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/10/10 06:00
MHDA- 2016/09/07 06:00
CRDT- 2014/10/10 06:00
PHST- 2014/06/25 00:00 [received]
PHST- 2014/08/24 00:00 [accepted]
PHST- 2014/08/24 00:00 [revised]
PHST- 2014/10/10 06:00 [entrez]
PHST- 2014/10/10 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - VM/OJS/J/38727 [pii]
AID - 10.5603/CJ.a2014.0068 [doi]
PST - ppublish
SO  - Cardiol J. 2015;22(3):285-9. doi: 10.5603/CJ.a2014.0068. Epub 2014 Oct 9.