PMID- 25300473
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20141208
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 123
DP  - 2014 Nov 1
TI  - beta-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform 
      for entrapment of guanine-based drugs.
PG  - 264-70
LID - S0927-7765(14)00496-2 [pii]
LID - 10.1016/j.colsurfb.2014.09.025 [doi]
AB  - The design of beta-cyclodextrin/multiwalled carbon nanotubes hybrid (beta-CD-MWCNT) as 
      nanoplatform for the entrapment and delivery of guanine based drugs is described 
      here. The functionalized carbon nanomaterials have been characterized by XPS 
      spectroscopy, electron microscopy (FEG-SEM and TEM), AFM, TGA, and FT-IR to 
      achieve insights on structure, morphology and chemical composition. The drug 
      binding abilities of nanocarrier towards the guanine (G) and Acyclovir (Acy) were 
      proved by UV-vis and DSC experiments. Host-guest equilibrium association 
      constants and drug loading have been evaluated for G/beta-CD-MWCNT and 
      Acy/beta-CD-MWCNT complexes. The release studies showed a sustained delivery of Acy 
      without initial burst effect confirming a strong interaction of drug with the 
      nanoplatform sites. The preliminary antiviral data indicated that the Acyclovir 
      loaded into the beta-CD-MWCNT platform interferes with HSV-1 replication and the 
      antireplicative effect was higher than the free drug.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Iannazzo, Daniela
AU  - Iannazzo D
AD  - Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, 
      Universita di Messina, C.da di Dio, 98166 Messina, Italy.
FAU - Mazzaglia, Antonino
AU  - Mazzaglia A
AD  - Consiglio Nazionale delle Ricerche CNR-ISMN c/o Dip. di Scienze Chimiche 
      dell'Universita di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 
      Messina, Italy. Electronic address: antonino.mazzaglia@ismn.cnr.it.
FAU - Scala, Angela
AU  - Scala A
AD  - Consiglio Nazionale delle Ricerche CNR-ISMN c/o Dip. di Scienze Chimiche 
      dell'Universita di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 
      Messina, Italy.
FAU - Pistone, Alessandro
AU  - Pistone A
AD  - Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, 
      Universita di Messina, C.da di Dio, 98166 Messina, Italy.
FAU - Galvagno, Signorino
AU  - Galvagno S
AD  - Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, 
      Universita di Messina, C.da di Dio, 98166 Messina, Italy.
FAU - Lanza, Maurizio
AU  - Lanza M
AD  - Consiglio Nazionale delle Ricerche CNR-IPCF, Viale Ferdinando Stagno D'Alcontres, 
      98166 Messina, Italy.
FAU - Riccucci, Cristina
AU  - Riccucci C
AD  - Consiglio Nazionale delle Ricerche CNR-ISMN, UOS Montelibretti, Via Salaria, 
      00015 Monterotondo Stazione, Rome, Italy.
FAU - Ingo, Gabriel Maria
AU  - Ingo GM
AD  - Consiglio Nazionale delle Ricerche CNR-ISMN, UOS Montelibretti, Via Salaria, 
      00015 Monterotondo Stazione, Rome, Italy.
FAU - Colao, Ivana
AU  - Colao I
AD  - Dipartimento di Scienze Biologiche e Ambientali, Universita di Messina, Viale 
      Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Sciortino, Maria Teresa
AU  - Sciortino MT
AD  - Dipartimento di Scienze Biologiche e Ambientali, Universita di Messina, Viale 
      Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
FAU - Valle, Francesco
AU  - Valle F
AD  - Consiglio Nazionale delle Ricerche CNR-ISMN, Via Piero Gobetti 101, 40129 
      Bologna, Italy.
FAU - Piperno, Anna
AU  - Piperno A
AD  - Dipartimento di Scienze Chimiche, Universita di Messina, Viale Ferdinando Stagno 
      D'Alcontres 31, 98166 Messina, Italy. Electronic address: apiperno@unime.it.
FAU - Grassi, Giovanni
AU  - Grassi G
AD  - Dipartimento di Scienze Chimiche, Universita di Messina, Viale Ferdinando Stagno 
      D'Alcontres 31, 98166 Messina, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140920
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (beta-Cyclodextrins)
RN  - 5Z93L87A1R (Guanine)
RN  - JV039JZZ3A (betadex)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/chemistry
MH  - Click Chemistry/methods
MH  - Guanine/*chemistry
MH  - Nanotubes, Carbon/*chemistry
MH  - beta-Cyclodextrins/*chemistry
OTO - NOTNLM
OT  - Acyclovir
OT  - Click chemistry
OT  - Guanine
OT  - Multiwalled carbon nanotubes
OT  - beta-Cyclodextrins
EDAT- 2014/10/11 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/10/11 06:00
PHST- 2014/05/30 00:00 [received]
PHST- 2014/09/01 00:00 [revised]
PHST- 2014/09/14 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - S0927-7765(14)00496-2 [pii]
AID - 10.1016/j.colsurfb.2014.09.025 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2014 Nov 1;123:264-70. doi: 
      10.1016/j.colsurfb.2014.09.025. Epub 2014 Sep 20.