PMID- 25301235
OWN - NLM
STAT- MEDLINE
DCOM- 20150728
LR  - 20191210
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 74
DP  - 2014 Dec
TI  - The effects of Betula platyphylla bark on amyloid beta-induced learning and 
      memory impairment in mice.
PG  - 156-63
LID - S0278-6915(14)00420-7 [pii]
LID - 10.1016/j.fct.2014.09.019 [doi]
AB  - Alzheimer's disease (AD) is closely associated with amyloid beta (Abeta)-induced 
      neurotoxicity and oxidative stress in the brain. Betula platyphylla, which has 
      been used to treat various oxidative-stressed related diseases, has recently 
      received attention for its preventive activity on age-related neurodegenerative 
      diseases. In this study, we attempted to investigate the effects of 
      B. platyphylla bark (BPB-316) on Abeta(1-42)-induced neurotoxicity and memory 
      impairment. Oral treatment using BPB-316 significantly attenuated Abeta-induced 
      memory impairment which was evaluated by behavioral tests including the passive 
      avoidance, Y-maze and Morris water maze test. BPB-316 also inhibited the 
      elevation of beta-secretase activity accompanying the reduced Abeta(1-42) levels in the 
      hippocampus of the brain. Furthermore, BPB-316 significantly decreased the 
      acetylcholinesterase activity and increased the glutathione content in the 
      hippocampus. In addition, we confirmed that the expression of both cAMP 
      responsive element-binding protein (CREB) and brain-derived neurotrophic factor 
      (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by 
      the treatment of BPB-316. Our data suggest that the extracts of B. platyphylla 
      bark might be a potential therapeutic agent against AD.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Cho, Namki
AU  - Cho N
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul 151-742, Republic of Korea.
FAU - Lee, Hee Kyoung
AU  - Lee HK
AD  - Institute for Life Science, Elcom Science Co. Ltd., Seoul, Republic of Korea.
FAU - Jeon, Byung Ju
AU  - Jeon BJ
AD  - Institute for Life Science, Elcom Science Co. Ltd., Seoul, Republic of Korea.
FAU - Kim, Hyeon Woo
AU  - Kim HW
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul 151-742, Republic of Korea.
FAU - Kim, Hong Pyo
AU  - Kim HP
AD  - College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea.
FAU - Lee, Jong-Hwan
AU  - Lee JH
AD  - Department of Veterinary Anatomy, College of Veterinary Medicine, Konkuk 
      University, Seoul, Republic of Korea.
FAU - Kim, Young Choong
AU  - Kim YC
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul 151-742, Republic of Korea.
FAU - Sung, Sang Hyun
AU  - Sung SH
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul 151-742, Republic of Korea. Electronic address: 
      shsung@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141006
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Peptide Fragments)
RN  - 0 (Plant Extracts)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.46 (Bace1 protein, mouse)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Amyloid Precursor Protein Secretases/biosynthesis/genetics
MH  - Amyloid beta-Peptides/*antagonists & inhibitors/*toxicity
MH  - Animals
MH  - Aspartic Acid Endopeptidases/biosynthesis/genetics
MH  - Avoidance Learning/drug effects
MH  - Betula/*chemistry
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Glutathione/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Learning Disabilities/*chemically induced/*prevention & control/psychology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced/*prevention & control/psychology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Peptide Fragments/*antagonists & inhibitors/*toxicity
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*pharmacology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid beta
OT  - Behavioral test
OT  - Betula platyphylla bark
OT  - CREB-BDNF pathway
EDAT- 2014/10/11 06:00
MHDA- 2015/07/29 06:00
CRDT- 2014/10/11 06:00
PHST- 2014/04/21 00:00 [received]
PHST- 2014/08/28 00:00 [revised]
PHST- 2014/09/29 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/07/29 06:00 [medline]
AID - S0278-6915(14)00420-7 [pii]
AID - 10.1016/j.fct.2014.09.019 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2014 Dec;74:156-63. doi: 10.1016/j.fct.2014.09.019. Epub 2014 
      Oct 6.