PMID- 25301274
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20231110
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Regulation of hemichannels and gap junction channels by cytokines in 
      antigen-presenting cells.
PG  - 742734
LID - 10.1155/2014/742734 [doi]
LID - 742734
AB  - Autocrine and paracrine signals coordinate responses of several cell types of the 
      immune system that provide efficient protection against different challenges. 
      Antigen-presenting cells (APCs) coordinate activation of this system via 
      homocellular and heterocellular interactions. Cytokines constitute chemical 
      intercellular signals among immune cells and might promote pro- or 
      anti-inflammatory effects. During the last two decades, two membrane pathways for 
      intercellular communication have been demonstrated in cells of the immune system. 
      They are called hemichannels (HCs) and gap junction channels (GJCs) and provide 
      new insights into the mechanisms of the orchestrated response of immune cells. 
      GJCs and HCs are permeable to ions and small molecules, including signaling 
      molecules. The direct intercellular transfer between contacting cells can be 
      mediated by GJCs, whereas the release to or uptake from the extracellular milieu 
      can be mediated by HCs. GJCs and HCs can be constituted by two protein families: 
      connexins (Cxs) or pannexins (Panxs), which are present in almost all APCs, being 
      Cx43 and Panx1 the most ubiquitous members of each protein family. In this 
      review, we focus on the effects of different cytokines on the intercellular 
      communication mediated by HCs and GJCs in APCs and their impact on purinergic 
      signaling.
FAU - Saez, Pablo J
AU  - Saez PJ
AUID- ORCID: 0000-0003-0521-9426
AD  - Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 
      340, 6513677 Santiago, Chile.
FAU - Shoji, Kenji F
AU  - Shoji KF
AD  - Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 
      340, 6513677 Santiago, Chile.
FAU - Aguirre, Adam
AU  - Aguirre A
AD  - Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 
      340, 6513677 Santiago, Chile.
FAU - Saez, Juan C
AU  - Saez JC
AD  - Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 
      340, 6513677 Santiago, Chile ; Instituto Milenio, Centro Interdisciplinario de 
      Neurociencias de Valparaiso, Pasaje Harrington 287, Playa Ancha, 2360103 
      Valparaiso, Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140909
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Connexins)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/*metabolism
MH  - Connexins/*metabolism
MH  - Cytokines/*metabolism
MH  - Gap Junctions/metabolism
MH  - Humans
PMC - PMC4180397
EDAT- 2014/10/11 06:00
MHDA- 2015/06/25 06:00
PMCR- 2014/09/09
CRDT- 2014/10/11 06:00
PHST- 2014/04/10 00:00 [received]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
PHST- 2014/09/09 00:00 [pmc-release]
AID - 10.1155/2014/742734 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:742734. doi: 10.1155/2014/742734. Epub 2014 Sep 9.