PMID- 25301574
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220331
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 13
DP  - 2014 Oct 11
TI  - Plasma triglycerides predict ten-years all-cause mortality in outpatients with 
      type 2 diabetes mellitus: a longitudinal observational study.
PG  - 135
LID - 10.1186/s12933-014-0135-6 [doi]
LID - 135
AB  - BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in type 2 
      diabetes mellitus (T2DM). American Diabetes Association standards of care set a 
      series of targets recommended for the CVD prevention: blood pressure, LDL and HDL 
      cholesterol (LDL-C and HDL-C), triglycerides and HbA1c goals. The aim of this 
      study was to evaluate cardiovascular risk factors in a T2DM outpatient population 
      in order to estimate their specific clinical value in predicting long-term 
      overall mortality. METHODS: Our study population was composed of 1917 T2DM 
      outpatients attending the hospital-based Diabetes Clinic of Ferrara for a mean 
      follow-up period of 10 years; recorded information included personal, clinical 
      and biochemical data, and pharmacological treatment. RESULTS: A Cox proportional 
      hazard analysis was performed, pointing out as age (HR:1.08; IC95%: 1.06-1.11), 
      sex (males: HR:1.97; IC95%: 1.26-3.07), mean triglycerides levels during 
      follow-up (III vs I tertile: HR:1.87; IC95%: 1.12-3.12) and lipid-lowering 
      treatment (HR:0.56; IC95%: 0.35-0.90) were significantly associated with 
      all-cause mortality, independent of confounding factors such as mean values of 
      LDL-C, HDL-C, HbA1c, blood pressure, BMI, fasting glucose, and antihypertensive 
      and antidiabetic treatment. CONCLUSIONS: This finding suggests that more 
      attention should be given to the management of cardiovascular risk in type 2 
      diabetic patients with high triglycerides levels.
FAU - Miselli, Maria-Agata
AU  - Miselli MA
FAU - Nora, Edoardo Dalla
AU  - Nora ED
FAU - Passaro, Angelina
AU  - Passaro A
FAU - Tomasi, Franco
AU  - Tomasi F
FAU - Zuliani, Giovanni
AU  - Zuliani G
AD  - Department of Medical Sciences, Section of Internal and Cardiorespiratory 
      Medicine, University of Ferrara, Ferrara, Italy. zlngnn@unife.it.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20141011
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Biomarkers)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Mortality/trends
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Triglycerides/*blood
PMC - PMC4198794
EDAT- 2014/10/11 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/10/11
CRDT- 2014/10/11 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/09/18 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/10/11 00:00 [pmc-release]
AID - s12933-014-0135-6 [pii]
AID - 135 [pii]
AID - 10.1186/s12933-014-0135-6 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2014 Oct 11;13:135. doi: 10.1186/s12933-014-0135-6.