PMID- 25301671
OWN - NLM
STAT- MEDLINE
DCOM- 20150721
LR  - 20221109
IS  - 1873-569X (Electronic)
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 77
IP  - 2
DP  - 2015 Feb
TI  - Human skin dendritic cells in health and disease.
PG  - 85-92
LID - S0923-1811(14)00211-4 [pii]
LID - 10.1016/j.jdermsci.2014.08.012 [doi]
AB  - Dendritic cells (DCs) are specialized antigen presenting cells abundant in 
      peripheral tissues such as skin where they function as immune sentinels. Skin DCs 
      migrate to draining lymph node where they interact with naive T cells to induce 
      immune responses to microorganisms, vaccines, tumours and self-antigens. In this 
      review, we present the key historical developments and recent advances in human 
      skin DC research. We also integrate the current understanding on the origin and 
      functional specializations of DC subsets in healthy skin with findings in 
      inflammatory skin diseases focusing on psoriasis and atopic eczema. A 
      comprehensive understanding of the dynamic changes in DC subsets in health and 
      disease will form a strong foundation to facilitate the clinical translation of 
      DC-based therapeutic and vaccination strategies.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights 
      reserved.
FAU - Haniffa, Muzlifah
AU  - Haniffa M
AD  - Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK; Department of 
      Dermatology, Newcastle Upon Tyne NHS Trust, NE1 4LP, UK. Electronic address: 
      m.a.haniffa@ncl.ac.uk.
FAU - Gunawan, Merry
AU  - Gunawan M
AD  - Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK.
FAU - Jardine, Laura
AU  - Jardine L
AD  - Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK.
LA  - eng
GR  - WT088555/Wellcome Trust/United Kingdom
GR  - WT097941/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140910
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (Antigens, Surface)
RN  - 0 (CD11 Antigens)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
SB  - IM
MH  - Antigens, Surface/physiology
MH  - CD11 Antigens/physiology
MH  - Dermatitis, Atopic/*immunology/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - Langerhans Cells/classification/*immunology/pathology
MH  - Lipopolysaccharide Receptors/physiology
MH  - Mononuclear Phagocyte System/physiology
MH  - Psoriasis/*immunology/pathology
MH  - Thrombomodulin
PMC - PMC4728191
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Dendritic cells
OT  - Mononuclear phagocytes
OT  - Skin
EDAT- 2014/10/11 06:00
MHDA- 2015/07/22 06:00
PMCR- 2015/02/01
CRDT- 2014/10/11 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/08/19 00:00 [revised]
PHST- 2014/08/28 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/07/22 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - S0923-1811(14)00211-4 [pii]
AID - 10.1016/j.jdermsci.2014.08.012 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2015 Feb;77(2):85-92. doi: 10.1016/j.jdermsci.2014.08.012. Epub 
      2014 Sep 10.