PMID- 25302724
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20141011
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 44
IP  - 10
DP  - 2014 Oct
TI  - Haploidentical peripheral blood stem cell infusion in combination with 
      chemotherapy for acute myeloid leukaemia in elderly patients.
PG  - 1038-40
LID - 10.1111/imj.12551 [doi]
AB  - Elderly patients with acute myeloid leukaemia (AML) have a poor prognosis with 
      standard chemotherapy. Two elderly AML patients treated with infusion of 
      family-derived partially human leukocyte antigen (HLA)-matched peripheral blood 
      stem cells following each cycle of chemotherapy entered morphological complete 
      remission without graft versus host disease or major toxicity. Our results 
      support this as a non-toxic approach for inducing a graft versus leukaemia effect 
      in patients not suitable for allogeneic transplantation. Additional resources 
      required for donor assessment and harvest may be reduced by using banked 
      partially HLA-matched mononuclear cells from unrelated donors.
CI  - (c) 2014 The Authors; Internal Medicine Journal (c) 2014 Royal Australasian College 
      of Physicians.
FAU - Bishop, D C
AU  - Bishop DC
AD  - Department of Haematology, Westmead Hospital, Sydney, New South Wales, Australia; 
      Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
FAU - Johnston, A J
AU  - Johnston AJ
FAU - Kwan, J M W
AU  - Kwan JM
FAU - Antonenas, V
AU  - Antonenas V
FAU - Gottlieb, D J
AU  - Gottlieb DJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 04079A1RDZ (Cytarabine)
RN  - BZ114NVM5P (Mitoxantrone)
SB  - IM
MH  - Aged
MH  - Antimetabolites, Antineoplastic/administration & dosage
MH  - *Antineoplastic Combined Chemotherapy Protocols
MH  - Cytarabine/administration & dosage
MH  - Disease-Free Survival
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Leukemia, Myeloid, Acute/blood/*drug therapy
MH  - Male
MH  - Mitoxantrone/administration & dosage
MH  - Prognosis
MH  - Prospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - acute myeloid leukaemia
OT  - adoptive cellular immunotherapy
OT  - aged
OT  - antineoplastic combined chemotherapy protocol/therapeutic use
OT  - hematopoietic stem cell transplantation
EDAT- 2014/10/11 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/10/11 06:00
PHST- 2014/01/14 00:00 [received]
PHST- 2014/06/22 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1111/imj.12551 [doi]
PST - ppublish
SO  - Intern Med J. 2014 Oct;44(10):1038-40. doi: 10.1111/imj.12551.