PMID- 25303484
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20220409
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 100
IP  - 1
DP  - 2015 Jan
TI  - Circulating betatrophin levels are increased in patients with type 2 diabetes and 
      associated with insulin resistance.
PG  - E96-100
LID - 10.1210/jc.2014-2300 [doi]
AB  - CONTEXT: Betatrophin has recently attracted increasing interests as a potential 
      beta-cell regenerative therapy in diabetes. However, differences in betatrophin 
      profiles in patients with type 2 diabetes mellitus (T2DM) remain unclear. 
      OBJECTIVE: The objective of the study was to examine circulating betatrophin 
      levels in subjects with different glucose tolerance status and its correlation 
      with insulin resistance. DESIGN, SETTING, AND PARTICIPANTS: Serum betatrophin 
      levels were measured using an ELISA in age-, sex-, body mass index-, and blood 
      lipid-matched subjects with normal glucose tolerance (n = 137), isolated impaired 
      fasting glucose (n = 69), isolated impaired glucose tolerance (n = 120), and 
      newly diagnosed T2DM (n = 112) from the Risk Evaluation of Cancers in Chinese 
      Diabetic Individuals: A Longitudinal study. RESULTS: Serum betatrophin levels 
      were elevated in patients with T2DM compared with subjects with normal glucose 
      tolerance, isolated impaired fasting glucose, or isolated impaired glucose 
      tolerance (798.6 +/- 42.5 vs 692.7 +/- 29.0, P < .05, vs 682.7 +/- 43.0, P < .05, vs 
      646.8 +/- 34.3 pg/mL, P < .01). Betatrophin levels positively correlated with the 
      index of homeostasis model assessment of insulin resistance (partial r = 0.11); 
      inversely correlated with quantitative insulin sensitivity check index (partial r 
      = -0.11), the Gutt insulin sensitivity index (partial r = -0.12), and the Matsuda 
      insulin sensitivity index (partial r = -0.11) after controlling for age, sex, 
      body mass index, and blood lipid in all participants (all values of P < .05). 
      CONCLUSION: Circulating betatrophin levels are increased in patients with T2DM 
      and associated with indexes of insulin resistance.
FAU - Chen, Xi
AU  - Chen X
AD  - Division of Endocrinology (X.C., P.L., W.H., J.Z., Y.Y., Z.L., J.X., S.S., T.D., 
      X.S., X.Z., S.H., G.Y., M.Z., X.Y.), Department of Internal Medicine, Division of 
      Cardiology (Le.L., D.W.), Department of Internal Medicine, Department of 
      Ophthalmology (H.Z.), Tongji Hospital, and Department of Nutrition and Food 
      Hygiene (Li.L.), School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430030, Hubei Province, People's 
      Republic of China.
FAU - Lu, Puhan
AU  - Lu P
FAU - He, Wentao
AU  - He W
FAU - Zhang, Jianhua
AU  - Zhang J
FAU - Liu, Lei
AU  - Liu L
FAU - Yang, Yan
AU  - Yang Y
FAU - Liu, Zhelong
AU  - Liu Z
FAU - Xie, Junhui
AU  - Xie J
FAU - Shao, Shiying
AU  - Shao S
FAU - Du, Tingting
AU  - Du T
FAU - Su, Xianghui
AU  - Su X
FAU - Zhou, Xinrong
AU  - Zhou X
FAU - Hu, Shuhong
AU  - Hu S
FAU - Yuan, Gang
AU  - Yuan G
FAU - Zhang, Muxun
AU  - Zhang M
FAU - Zhang, Hong
AU  - Zhang H
FAU - Liu, Liegang
AU  - Liu L
FAU - Wang, Daowen
AU  - Wang D
FAU - Yu, Xuefeng
AU  - Yu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Peptide Hormones/*blood
MH  - Prediabetic State/*blood
EDAT- 2014/10/11 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/10/11 06:00
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1210/jc.2014-2300 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2015 Jan;100(1):E96-100. doi: 10.1210/jc.2014-2300.