PMID- 25303644
OWN - NLM
STAT- MEDLINE
DCOM- 20160902
LR  - 20220409
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 16
IP  - 8
DP  - 2015 Dec
TI  - Association between triglyceride to HDL-C ratio and insulin resistance in 
      indigenous Argentinean children.
PG  - 606-12
LID - 10.1111/pedi.12228 [doi]
AB  - BACKGROUND: Insulin resistance is considered one of the major risk factors for 
      the development of type 2 diabetes mellitus (T2DM). Thus, early identification, 
      preferably by using simple and inexpensive diagnostic tools, is essential for 
      preventing T2DM. Triglyceride (TG) to high-density lipoprotein cholesterol 
      (HDL-C) ratio (TG/HDL-C) has been proposed as an inexpensive tool to identify 
      individuals at high risk of T2DM. The objective of this study was to determine 
      the relationship between insulin resistance and TG/HDL-C in indigenous 
      Argentinean children. METHODS: A cross-sectional study of 501 (243 boys) 
      indigenous school children aged 10.0 +/- 2.4 yr were assessed for anthropometry, 
      lipids, glucose, and insulin levels from November 2011 to November 2013. Insulin 
      resistance was defined as the upper third quartile of homeostasis model 
      assessment (HOMA-IR). RESULTS: The prevalence of overweight/obesity was 11.4% per 
      Centers for Disease Control. Mean levels of various characteristics were: body 
      mass index (BMI) 17.2 +/- 2.6, HDL-C 39 +/- 9 mg/dL, TGs 121 +/- 58 mg/dL, TG/HDL-C 2.9 
      +/- 1.8, glucose 77 +/- 8 mg/dL, HOMA-IR 1.0 +/- 0.8, and insulin 44 +/- 9 mUI/L. 
      Children in the higher quartiles of TG/HDL-C had significantly higher HOMA-IR 
      values than children in the lower quartiles. Multiple linear regression analysis 
      showed that TG/HDL-C was significantly associated with HOMA-IR (r(2) = 0.19) 
      adjusted for age, gender, and BMI. Furthermore, for a 1-unit increase in log 
      TG/HDL-C, the odds of being insulin resistant (HOMA-IR>III quartile) increased by 
      2.58 times [odds ratio (OR), 2.58 (1.63-4.05); p < 0.01], adjusted for age, 
      gender, and BMI. CONCLUSION: This study suggests that TG/HDL-C may be a good 
      marker to identify insulin resistant indigenous Argentinean children.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hirschler, V
AU  - Hirschler V
AD  - Universidad de Buenos Aires, Buenos Aires, Argentina.
FAU - Maccallini, G
AU  - Maccallini G
AD  - Hidalgo Laboratories, Buenos Aires, Argentina.
FAU - Sanchez, M
AU  - Sanchez M
AD  - Hidalgo Laboratories, Buenos Aires, Argentina.
FAU - Gonzalez, C
AU  - Gonzalez C
AD  - Universidad de Buenos Aires, Buenos Aires, Argentina.
FAU - Molinari, C
AU  - Molinari C
AD  - Universidad de Buenos Aires, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20141010
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adolescent
MH  - Argentina/ethnology
MH  - Child
MH  - Cholesterol, HDL/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Sex Factors
MH  - Triglycerides/*blood
OTO - NOTNLM
OT  - TG/HDL-C
OT  - indigenous children
OT  - insulin resistance
EDAT- 2014/10/11 06:00
MHDA- 2016/09/03 06:00
CRDT- 2014/10/11 06:00
PHST- 2014/06/14 00:00 [received]
PHST- 2014/09/12 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2014/10/11 06:00 [pubmed]
PHST- 2016/09/03 06:00 [medline]
AID - 10.1111/pedi.12228 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2015 Dec;16(8):606-12. doi: 10.1111/pedi.12228. Epub 2014 Oct 
      10.