PMID- 25304065
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20151119
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 177
IP  - 2
DP  - 2014 Dec 15
TI  - Right ventricular dysfunction, late gadolinium enhancement, and female gender 
      predict poor outcome in patients with dilated cardiomyopathy.
PG  - 429-35
LID - S0167-5273(14)01706-9 [pii]
LID - 10.1016/j.ijcard.2014.09.004 [doi]
AB  - AIMS: Dilated cardiomyopathy (DCM) shows a variable disease course and is 
      associated with significant morbidity and mortality. So far, left ventricular 
      function (LVF) is the major determinant for risk stratification. However, since 
      it has shown to be a poor guide to individual outcome, we studied the prognostic 
      value of cardiovascular magnetic resonance imaging (CMR) parameters, late 
      gadolinium enhancement (LGE) and epicardial adipose tissue (EAT). METHODS AND 
      RESULTS: 140 patients with DCM underwent late gadolinium enhancement (LGE) CMR. 
      During a median follow-up of 3 years, 22 patients (16%) died and another 51 (36%) 
      were hospitalized due to congestive heart failure (CHF). Female gender and right 
      ventricular ejection fraction (RV-EF) below the median of 38% were independent 
      predictors of all-cause mortality in multivariable analysis. In patients who were 
      hospitalized due to CHF, RV-EF below the median of 38% was the only independent 
      predictor in multivariable analysis. When patients where further stratified 
      according to systolic LV-EF, the prognostic value of RV-EF to predict mortality 
      and cardiac morbidity remained unchanged. Looking at DCM patients who died during 
      follow-up compared to those who were hospitalized due to CHF, the former 
      presented with a higher prevalence of LGE as well as reduced indexed EAT. 
      CONCLUSION: Female gender, RV-EF and the presence of LGE are of prognostic 
      importance in patients with DCM. Therefore, the present study underlines the role 
      of CMR as an important tool for risk stratification in patients with DCM.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Doesch, Christina
AU  - Doesch C
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany. Electronic address: 
      Christina.Doesch@umm.de.
FAU - Dierks, Desiree-Marie
AU  - Dierks DM
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany.
FAU - Haghi, Dariusch
AU  - Haghi D
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Schimpf, Rainer
AU  - Schimpf R
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Kuschyk, Jurgen
AU  - Kuschyk J
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Suselbeck, Tim
AU  - Suselbeck T
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Schoenberg, Stefan O
AU  - Schoenberg SO
AD  - Institute of Clinical Radiology and Nuclear Medicine, University Medical Center 
      Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK 
      (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Borggrefe, Martin
AU  - Borggrefe M
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
FAU - Papavassiliu, Theano
AU  - Papavassiliu T
AD  - 1st Department of Medicine, Cardiology, University Medical Centre Mannheim, 
      Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre 
      for Cardiovascular Research) partner site, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/*diagnosis/mortality/*physiopathology
MH  - Female
MH  - *Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - *Sex Characteristics
MH  - Survival Rate/trends
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Right/*diagnosis/mortality/*physiopathology
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance imaging
OT  - Dilated cardiomyopathy
OT  - Right ventricular ejection fraction
OT  - Risk stratification
EDAT- 2014/10/12 06:00
MHDA- 2015/08/19 06:00
CRDT- 2014/10/12 06:00
PHST- 2013/12/21 00:00 [received]
PHST- 2014/07/31 00:00 [revised]
PHST- 2014/09/15 00:00 [accepted]
PHST- 2014/10/12 06:00 [entrez]
PHST- 2014/10/12 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - S0167-5273(14)01706-9 [pii]
AID - 10.1016/j.ijcard.2014.09.004 [doi]
PST - ppublish
SO  - Int J Cardiol. 2014 Dec 15;177(2):429-35. doi: 10.1016/j.ijcard.2014.09.004. Epub 
      2014 Oct 7.