PMID- 25304280
OWN - NLM
STAT- MEDLINE
DCOM- 20150814
LR  - 20181202
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 24
IP  - 5
DP  - 2015 Jun-Jul
TI  - Evaluation of the retinal ganglion cell layer thickness in healthy Turkish 
      children.
PG  - e103-8
LID - 10.1097/IJG.0000000000000168 [doi]
AB  - PURPOSE: To identify the distribution, variation, and determinants of ganglion 
      cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children 
      measured by high-definition optical coherence tomography (HD-OCT). PATIENTS AND 
      METHODS: This institutional study involved 296 eyes from 296 healthy children 
      aged between 3 and 17 years. Each child underwent a dilated eye examination, 
      cycloplegic refraction, and axial length measurement using Nidek AL-Scan optical 
      biometer. Macular scan was used to measure the GC-IPL thickness, and 
      peripapillary retinal nerve fiber layer (RNFL) thickness was measured using the 
      HD-OCT (Cirrus HD-OCT). Right eye of each subject was selected for analysis. 
      RESULTS: A total of 296 children (125 boys, 171 girls) were included in this 
      study. The mean age of the children was 9.62+/-4.10 years (range, 3 to 17 y). The 
      mean spherical equivalent was -0.09+/-1.49 D. The mean AL was 23.03+/-1.03 mm. The 
      mean overall GC-IPL thickness was 83.44+/-5.52 mum and RNFL thickness was 
      96.91+/-10.21 mum. They were thicker than has been reported in adults. According to 
      age-adjusted multiple regression analyses significant predictors of mean GC-IPL 
      thickness were peripapillary RNFL thickness and AL (P<0.001). CONCLUSIONS: This 
      study ensures a pediatric normative database of GC-IPL using spectral-domain OCT. 
      This information may provide to diagnosis and monitoring of optic nerve diseases 
      and glaucoma in children.
FAU - Totan, Yuksel
AU  - Totan Y
AD  - Department of Ophthalmology, Turgut Ozal University, Medical School, Ankara, 
      Turkey.
FAU - Guragac, Fatma B
AU  - Guragac FB
FAU - Guler, Emre
AU  - Guler E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Axial Length, Eye/anatomy & histology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - *Nerve Fibers
MH  - Organ Size
MH  - Prospective Studies
MH  - Reference Values
MH  - Refraction, Ocular/physiology
MH  - Retinal Ganglion Cells/*cytology
MH  - Sex Factors
MH  - Tomography, Optical Coherence/*methods
MH  - Turkey
EDAT- 2014/10/12 06:00
MHDA- 2015/08/15 06:00
CRDT- 2014/10/12 06:00
PHST- 2014/10/12 06:00 [entrez]
PHST- 2014/10/12 06:00 [pubmed]
PHST- 2015/08/15 06:00 [medline]
AID - 10.1097/IJG.0000000000000168 [doi]
PST - ppublish
SO  - J Glaucoma. 2015 Jun-Jul;24(5):e103-8. doi: 10.1097/IJG.0000000000000168.