PMID- 25304692
OWN - NLM
STAT- MEDLINE
DCOM- 20150717
LR  - 20211203
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 194
DP  - 2014 Dec 19
TI  - Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of 
      rapamycin (mTOR) signalling pathways in porcine reproductive and respiratory 
      syndrome virus (PRRSV) replication.
PG  - 138-44
LID - S0168-1702(14)00404-3 [pii]
LID - 10.1016/j.virusres.2014.09.017 [doi]
AB  - Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a positive sense, 
      single-stranded RNA genome virus that has become a major infection in swine, 
      exerting huge economic losses to the industry worldwide. Detailed knowledge 
      concerning the molecular mechanisms by which the virus manipulates the host cell 
      signals transduction machinery is not only critical to further our understanding 
      of viral replication and pathogenesis, but also guides our efforts to design new 
      and improved therapeutic strategies. The phosphatidylinositol-3-kinase 
      (PI3K)-dependent Akt and the mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) 
      are major host cell signalling pathways that regulate protein synthesis, cell 
      growth, proliferation, migration and survival. It is also established that many 
      viruses exploit these signalling cascades for their own benefit, driving viral 
      protein expression, replication, as well as the suppression of the host's 
      antiviral activities. In this article, we will review the role of these 
      signalling pathways during PRRSV replication, and discuss some of our recent 
      findings implicating mTOR.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Pujhari, Sujit
AU  - Pujhari S
AD  - Vaccine and Infectious Disease Organization, International Vaccine Center 
      (VIDO-InterVac), University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, 
      S7N 5E3 Canada.
FAU - Kryworuchko, Marko
AU  - Kryworuchko M
AD  - School of Public Health, University of Saskatchewan, 104 Clinic Place, Saskatoon 
      SK, S7N 5E5, Canada.
FAU - Zakhartchouk, Alexander N
AU  - Zakhartchouk AN
AD  - Vaccine and Infectious Disease Organization, International Vaccine Center 
      (VIDO-InterVac), University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, 
      S7N 5E3 Canada. Electronic address: alex.zak@usask.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20141007
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - *Host-Pathogen Interactions
MH  - Phosphatidylinositol 3-Kinase/*metabolism
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - *Signal Transduction
MH  - Swine
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - *Virus Replication
OTO - NOTNLM
OT  - Akt
OT  - Autophagy
OT  - PRRSV
OT  - mTOR
EDAT- 2014/10/12 06:00
MHDA- 2015/07/18 06:00
CRDT- 2014/10/12 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2014/09/26 00:00 [revised]
PHST- 2014/09/29 00:00 [accepted]
PHST- 2014/10/12 06:00 [entrez]
PHST- 2014/10/12 06:00 [pubmed]
PHST- 2015/07/18 06:00 [medline]
AID - S0168-1702(14)00404-3 [pii]
AID - 10.1016/j.virusres.2014.09.017 [doi]
PST - ppublish
SO  - Virus Res. 2014 Dec 19;194:138-44. doi: 10.1016/j.virusres.2014.09.017. Epub 2014 
      Oct 7.