PMID- 25304745
OWN - NLM
STAT- MEDLINE
DCOM- 20150826
LR  - 20220129
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 439
DP  - 2015 Jan 15
TI  - Phospholipid transfer protein activity and incident type 2 diabetes mellitus.
PG  - 38-41
LID - S0009-8981(14)00431-8 [pii]
LID - 10.1016/j.cca.2014.09.035 [doi]
AB  - BACKGROUND: The plasma activity of phospholipid transfer protein (PLTP), which 
      has multifaceted functions in lipoprotein metabolism and in inflammatory 
      responses, is elevated in insulin resistant conditions. We determined the 
      association of plasma PLTP activity with incident type 2 diabetes mellitus 
      (T2DM). METHODS: Plasma PLTP activity was determined using a liposome vesicle-HDL 
      system in 218 men without T2DM at baseline. We used logistic regression models to 
      establish odds ratios (ORs) for incident T2DM. RESULTS: Twenty four men developed 
      T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM 
      cases (p=0.009). We observed 82% higher odds for T2DM per 1-SD increase in PLTP 
      activity. Multivariable modeling showed that the association of PLTP activity 
      with T2DM was independent of clinical risk factors including age, and either the 
      metabolic syndrome, individual metabolic syndrome components, total cholesterol, 
      HOMA-IR or albuminuria (ORs ranging from 1.64 (95% CI 1.03-2.66) to 1.87 
      (1.19-3.010)). CONCLUSIONS: Elevated plasma PLTP activity may predict an 
      increased risk of T2DM in men.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Abbasi, Ali
AU  - Abbasi A
AD  - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, 
      Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's 
      Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK; Department of Epidemiology, 
      University of Groningen, University Medical Center Groningen, Groningen, the 
      Netherlands; Department of Internal Medicine, University of Groningen, University 
      Medical Center Groningen, Groningen, the Netherlands.
FAU - Dallinga-Thie, Geesje M
AU  - Dallinga-Thie GM
AD  - Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, 
      the Netherlands.
FAU - Dullaart, Robin P F
AU  - Dullaart RP
AD  - Department of Internal Medicine, University of Groningen, University Medical 
      Center Groningen, Groningen, the Netherlands. Electronic address: 
      r.p.f.dullaart@umcg.nl.
LA  - eng
GR  - MC_UU_12015/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_U106179471/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (PLTP protein, human)
RN  - 0 (Phospholipid Transfer Proteins)
SB  - IM
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phospholipid Transfer Proteins/blood/*metabolism
OTO - NOTNLM
OT  - Epidemiology
OT  - Phospholipid transfer protein activity
OT  - Risk factor
OT  - Type 2 diabetes mellitus
EDAT- 2014/10/12 06:00
MHDA- 2015/08/27 06:00
CRDT- 2014/10/12 06:00
PHST- 2014/09/15 00:00 [received]
PHST- 2014/09/29 00:00 [revised]
PHST- 2014/09/30 00:00 [accepted]
PHST- 2014/10/12 06:00 [entrez]
PHST- 2014/10/12 06:00 [pubmed]
PHST- 2015/08/27 06:00 [medline]
AID - S0009-8981(14)00431-8 [pii]
AID - 10.1016/j.cca.2014.09.035 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2015 Jan 15;439:38-41. doi: 10.1016/j.cca.2014.09.035. Epub 2014 
      Oct 7.