PMID- 25304916
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20150429
IS  - 1872-7131 (Electronic)
IS  - 0387-7604 (Linking)
VI  - 37
IP  - 6
DP  - 2015 Jun
TI  - Alterations of proliferation and differentiation of hippocampal cells in 
      prenatally stressed rats.
PG  - 563-71
LID - S0387-7604(14)00219-8 [pii]
LID - 10.1016/j.braindev.2014.09.007 [doi]
AB  - PURPOSE: To clarify the alterations of proliferation and differentiation of 
      hippocampal cells in prenatally stressed rats. METHODS: We investigated the 
      impact of prenatal restraint stress on the hipocampal cell proliferation in the 
      progeny with 5-bromo-2'-deoxyuridine (BrdU), which is a marker of proliferating 
      cells and their progeny. In addition, we observed the differentiation of neural 
      stem cells (NSCs) with double labeling of BrdU/neurofilament (NF), BrdU/glial 
      fibrillary acidic protein (GFAP) in the hipocampus. RESULTS: Prenatal stress (PS) 
      increased cell proliferation in the dentate gyrus (DG) only in female and neuron 
      differentiation of newly divided cells in the DG and CA4 in both male and female. 
      Moreover, the NF and GFAP-positive cells, but not the BrdU-positive cells, 
      BrdU/NF and BrdU/GFAP-positive cells, were found frequently in the CA3 and CA1 in 
      the offspring of each group. CONCLUSIONS: These results possibly suggest a 
      compensatory adaptive response to neuronal damage or loss in hippocampus induced 
      by PS.
CI  - Copyright (c) 2014 The Japanese Society of Child Neurology. Published by Elsevier 
      B.V. All rights reserved.
FAU - Sun, Hongli
AU  - Sun H
AD  - Shaanxi Institute of Pediatric Diseases, The Affiliated Children Hospital of 
      Xi'an Jiaotong University College of Medicine, Shaanxi 86-710003, PR China.
FAU - Su, Qian
AU  - Su Q
AD  - Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi 86-710061, PR China.
FAU - Zhang, Huifang
AU  - Zhang H
AD  - The Affiliated Children Hospital of Xi'an Jiaotong University College of 
      Medicine, Shaanxi 86-710003, PR China.
FAU - Liu, Weimin
AU  - Liu W
AD  - Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi 86-710061, PR China.
FAU - Zhang, Huiping
AU  - Zhang H
AD  - Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi 86-710061, PR China.
FAU - Ding, Ding
AU  - Ding D
AD  - Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi 86-710061, PR China.
FAU - Zhu, Zhongliang
AU  - Zhu Z
AD  - Shaanxi Province Biomedicine Key Laboratory, College of Life Sciences, Northwest 
      University, Shaanxi 86-710069, PR China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi 86-710061, PR China; The Affiliated Children Hospital of 
      Xi'an Jiaotong University College of Medicine, Shaanxi 86-710003, PR China. 
      Electronic address: huili@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141007
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Female
MH  - Hippocampus/*physiopathology
MH  - Male
MH  - Neural Stem Cells/*physiology
MH  - Neurons/*physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Sex Factors
MH  - Stress, Psychological/*physiopathology
OTO - NOTNLM
OT  - BrdU
OT  - Glial fibrillary acidic protein
OT  - Hippocampus
OT  - Neurofilament
OT  - Prenatal stress
EDAT- 2014/10/12 06:00
MHDA- 2016/01/14 06:00
CRDT- 2014/10/12 06:00
PHST- 2014/07/17 00:00 [received]
PHST- 2014/09/10 00:00 [revised]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/10/12 06:00 [entrez]
PHST- 2014/10/12 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - S0387-7604(14)00219-8 [pii]
AID - 10.1016/j.braindev.2014.09.007 [doi]
PST - ppublish
SO  - Brain Dev. 2015 Jun;37(6):563-71. doi: 10.1016/j.braindev.2014.09.007. Epub 2014 
      Oct 7.