PMID- 25305
OWN - NLM
STAT- MEDLINE
DCOM- 19780628
LR  - 20031114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 120
IP  - 4
DP  - 1978 Apr
TI  - Studies on the mitogen responses of germfree allogeneic chimeras. II. Maturation 
      of two cell types and partial restoration of responsiveness of the short-term 
      chimeras.
PG  - 1274-7
AB  - Germfree allogeneic bone marrow chimeras (ABMC) were produced by the i.v. 
      injection of approximately 10(7) bone marrow cells from germfree DBA/2 mice into 
      lethally irradiated germfree C3H mice. In the germfree state, the short-term ABMC 
      showed no histologic signs of graft-vs-host reactions (GVHR), yet splenic 
      lymphocytes were unable to respond to PHA, Con A, or SRBC. Attempts to remove 
      responsiveness by the implantation of a DBA/2 thymus under the host kidney 
      capsule also resulted in failure. However, when the donor thymus was enclosed in 
      a cell-impermeable chamber to eliminate a GVH reaction, responsiveness to Con A 
      was restored. The PHA and SRBC responses were unaffected by this treatment. Daily 
      injections of thymosin caused both an increased Con A response and increased 
      numbers of PFC, although the PHA response was again unaffected. Thus, soluble 
      substances from thymic tissue can be used to overcome partially the 
      histocompatibility barrier present in the ABMC that affects at least two 
      different functional cell populations.
FAU - Mattingly, J A
AU  - Mattingly JA
FAU - Webb, P M
AU  - Webb PM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Lectins)
RN  - 0 (Mitogens)
RN  - 11028-71-0 (Concanavalin A)
RN  - 61512-21-8 (Thymosin)
SB  - IM
MH  - Animals
MH  - Bone Marrow/immunology
MH  - Concanavalin A/pharmacology
MH  - Female
MH  - *Germ-Free Life
MH  - Graft vs Host Reaction
MH  - Lectins/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred DBA
MH  - Mitogens/*pharmacology
MH  - *Radiation Chimera
MH  - Thymosin/pharmacology
MH  - Thymus Gland/transplantation
MH  - Time Factors
MH  - Transplantation, Homologous
EDAT- 1978/04/01 00:00
MHDA- 1978/04/01 00:01
CRDT- 1978/04/01 00:00
PHST- 1978/04/01 00:00 [pubmed]
PHST- 1978/04/01 00:01 [medline]
PHST- 1978/04/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1978 Apr;120(4):1274-7.