PMID- 25305432 OWN - NLM STAT- MEDLINE DCOM- 20150518 LR - 20181202 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 171 DP - 2015 Jan 15 TI - Decreased plasma levels of brain-derived neurotrophic factor (BDNF) during mixed episodes of bipolar disorder. PG - 167-70 LID - S0165-0327(14)00562-X [pii] LID - 10.1016/j.jad.2014.08.058 [doi] AB - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neurogenesis and neuroplasticity. Decreased blood levels of BDNF have been found during acute manic and depressive states. BDNF has been proposed as a biomarker in illness phases of mood disorders. No information is available regarding BDNF levels during the mixed states of bipolar disorder (BD). The aim of this study was to evaluate BDNF levels during mixed episodes of BD patients and compare them with those of healthy subjects and depressed patients. METHODS: Plasma BDNF levels were measured by an ELISA assay in 18 patients with major depressive episode (MDE), 19 patients with mixed episode (ME) and 15 healthy subjects (HS). RESULTS: BDNF levels were significantly higher in HS, as compared with patients׳ samples (HS vs. MDE patients: p<001; HS vs. ME patients: p=.022). No significant differences were found between BDNF levels of ME and MDE patients. The severity of illness as assessed by CGI-S was significantly higher in ME than in MDE patients (p=.01). LIMITATIONS: The small sample size may have weakened the power of statistical analyses. All patients received mood-stabilizing and antidepressant treatments which have been reported to influence peripheral BDNF levels. CONCLUSIONS: Our results are consistent with previous studies showing reduced BDNF during both manic and depressive episodes. This finding supports the role of BDNF as a state-marker of mood episodes, and may represent a contribution to a unitary approach model between unipolar and BDs, as well as to the manic-depressive spectrum model. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Piccinni, Armando AU - Piccinni A AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: armando.piccinni@gmail.com. FAU - Veltri, Antonello AU - Veltri A AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Costanzo, Davide AU - Costanzo D AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Vanelli, Federica AU - Vanelli F AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Franceschini, Caterina AU - Franceschini C AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Moroni, Ilenia AU - Moroni I AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Domenici, Luciano AU - Domenici L AD - Neuroscience Institute, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy; Department DISCAB, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy. FAU - Origlia, Nicola AU - Origlia N AD - Neuroscience Institute, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy. FAU - Marazziti, Donatella AU - Marazziti D AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. FAU - Akiskal, Hagop Souren AU - Akiskal HS AD - International Mood Center, University of California, San Diego, CA, USA. FAU - Dell'Osso, Liliana AU - Dell'Osso L AD - Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy. LA - eng PT - Journal Article DEP - 20140928 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Analysis of Variance MH - Biomarkers/blood MH - Bipolar Disorder/*blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder, Major/blood MH - Enzyme-Linked Immunosorbent Assay/methods MH - Female MH - Humans MH - Male MH - Severity of Illness Index OTO - NOTNLM OT - BDNF OT - Biomarkers OT - Bipolar disorder OT - Bipolar spectrum OT - DSM-5 OT - Mixed state EDAT- 2014/10/12 06:00 MHDA- 2015/05/20 06:00 CRDT- 2014/10/12 06:00 PHST- 2014/03/12 00:00 [received] PHST- 2014/08/29 00:00 [accepted] PHST- 2014/10/12 06:00 [entrez] PHST- 2014/10/12 06:00 [pubmed] PHST- 2015/05/20 06:00 [medline] AID - S0165-0327(14)00562-X [pii] AID - 10.1016/j.jad.2014.08.058 [doi] PST - ppublish SO - J Affect Disord. 2015 Jan 15;171:167-70. doi: 10.1016/j.jad.2014.08.058. Epub 2014 Sep 28.