PMID- 25307244
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20141013
IS  - 0103-507X (Print)
IS  - 0103-507X (Linking)
VI  - 20
IP  - 4
DP  - 2008 Dec
TI  - Renal function of intensive care unit patients: plasma creatinine and urinary 
      retinol-binding protein.
PG  - 385-93
LID - S0103-507X2008000400011 [pii]
AB  - OBJECTIVES: The early assessment of renal dysfunction using common markers does 
      not provide either a sensitive or specific indication of renal dysfunction in 
      critically ill patients. More specific and sensitive markers are desirable for 
      the early detection of an initial renal pathophysiological process. Urinary 
      retinol-binding protein could be an alternative method to early evaluation of 
      renal function in these patients. METHODS: This study followed-up 100 critical 
      care patients and assessed their clinical and laboratory variables, including 
      plasma creatinine and urinary retinol-binding ratio, and demographic variables. 
      RESULTS: The sample was characterized by geriatric (63.4+/-15.6 years), male (68%), 
      being 53% surgical patients. Statistical analysis showed association between 
      plasma creatinine and the following variables: gender (p-0.026), age (p-0.038), 
      use of vasoactive drugs (p-0.003), proteinuria (p-0.025), Acute Physiological 
      Chronic Health Evaluation (APACHE) II score (p-0.000), urea (p-0.000), potassium 
      (p-0.003) and estimated creatinine clearance (p-0.000). Urinary retinol-binding 
      protein was correlated with more variables: weight, use of invasive ventilation 
      (p-0.000), use of nonsteroidal antiinflammatory drugs (p-0.018), use of 
      vasoactive drugs (p-0.021), high temperature (>37.5 masculineC) (p-0.005), proteinuria 
      (p-0.000), bilirubinuria (p-0.004), urinary flow (p-0.019), minimal diastolic 
      pressure (p-0.032), minimal systolic pressure (p-0.029), APACHE II (p-0.000), 
      creatinine (p-0.001), urea (p-0.001), estimated creatinine clearance (p-0.000). 
      Urinary retinol-binding protein also tended to associate with previous renal 
      disease, vasculopathy and neoplasm. Sodium excretion fraction correlated with 
      plasma creatinine and urinary retinol-binding protein in univariate analysis. 
      CONCLUSIONS: Urinary retinol-binding protein might be considered in clinical 
      practice as a better marker regarding diagnostic performance in patients at risk 
      of developing acute kidney injury, when compared with other markers routinely 
      used. Moreover, urinary retinol-binding protein has other features of a good 
      diagnostic test - it is a practical and non-invasive method.
FAU - Mizoi, Cristina Satoko
AU  - Mizoi CS
AD  - Hospital Istraelita Albert Einstein, Sao Paulo, SP, Brasil.
FAU - Dezoti, Cassiane
AU  - Dezoti C
AD  - Escola de Enfermagem, Universidade de Sao Paulo, Sao Paulo, SP.
FAU - Vattimo, Maria de Fatima Fernandes
AU  - Vattimo Mde F
AD  - Escola de Enfermagem, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Funcao renal de pacientes de unidade de terapia intensiva: creatinina plasmatica 
      e proteina carreadora do retinol urinario.
PL  - Brazil
TA  - Rev Bras Ter Intensiva
JT  - Revista Brasileira de terapia intensiva
JID - 9506692
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
CRDT- 2014/10/14 06:00
PHST- 2008/08/04 00:00 [received]
PHST- 2008/10/23 00:00 [accepted]
PHST- 2014/10/14 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
AID - S0103-507X2008000400011 [pii]
PST - ppublish
SO  - Rev Bras Ter Intensiva. 2008 Dec;20(4):385-93.