PMID- 25308403
OWN - NLM
STAT- MEDLINE
DCOM- 20150710
LR  - 20141203
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 26
IP  - 6
DP  - 2014 Dec
TI  - Brain-derived neurotrophic factor as a suicide factor in mental disorders.
PG  - 356-63
LID - 10.1017/neu.2014.27 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a critical role in 
      brain plasticity processes and serum levels have been demonstrated to be altered 
      in patients with different mental disorder including suicidal behaviour. The 
      objective of this study was to examine the association between serum BDNF levels 
      as a possible peripheral indicator of suicide behaviour in subjects suffering 
      from depression, personality disorders (PDs) and adjustment disorders (ADs) with 
      or without suicide attempt. METHODS: The research included 172 randomly selected 
      individuals suffering from recurrent depressive disorder (RDD; F 33.2), 
      emotionally unstable PD (F 60.3) and AD (F 43.2), with or without attempted 
      suicide according to the criteria of the ICD-10 (International Statistical 
      Classification of Diseases and Related Health Problems 10th Revision) and 60 
      phenotypically health control subjects. In the group of patients, 73% subjects 
      took some form of psychopharmacotherapy. Serum BDNF levels were measured by 
      enzyme linked immunosorbent assay. RESULTS: Subjects with PD and AD with suicide 
      attempts had significantly lower serum BDNF levels than those without suicide 
      attempts. In groups of subjects with PD and AD, those taking 
      psychopharmacotherapy had higher serum BDNF levels. In the group of subjects with 
      RDD, there were no differences with respect to suicide attempts or 
      psychopharmacotherapy. Logistical regression analysis was indicated that 
      psychopharmacotherapy and serum BDNF levels statistically correlated with suicide 
      attempts. CONCLUSION: The lower levels of BDNF in subjects suffering from PD and 
      AD with suicide attempts, suggest that the serum BDNF level is a potential marker 
      of suicidal behaviour, independent of mental disorders.
FAU - Grah, Majda
AU  - Grah M
AD  - 1Psychiatric Hospital 'Sveti Ivan',Department for the Treatment of Psychosis and 
      Borderline States,Jankomir,Zagreb,Croatia.
FAU - Mihanovic, Mate
AU  - Mihanovic M
AD  - 2Psychiatric Hospital 'Sveti Ivan',Jankomir,Zagreb,Croatia.
FAU - Ruljancic, Nedjeljka
AU  - Ruljancic N
AD  - 3Psychiatric Hospital 'Sveti Ivan',Department of Laboratory 
      Diagnostics,Jankomir,Zagreb,Croatia.
FAU - Restek-Petrovic, Branka
AU  - Restek-Petrovic B
AD  - 4Psychiatric Hospital 'Sveti Ivan',Department for Psychotherapeutic Treatment of 
      Neuroses,Psychoses,and Borderline States and Day 
      Hospital,Jankomir,Zagreb,Croatia.
FAU - Molnar, Sven
AU  - Molnar S
AD  - 5Psychiatric Hospital 'Sveti Ivan',Department of Neurosis and 
      PTSD,Jankomir,Zagreb,Croatia.
FAU - Jelavic, Silvana
AU  - Jelavic S
AD  - 6Psychiatric Hospital 'Sveti Ivan',Department of 
      Psychosis,Jankomir,Zagreb,Croatia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141013
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Mental Disorders/*blood/diagnosis/drug therapy/psychology
MH  - Middle Aged
MH  - *Suicide
MH  - Young Adult
EDAT- 2014/10/14 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/10/14 06:00
PHST- 2014/10/14 06:00 [entrez]
PHST- 2014/10/14 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0924270814000271 [pii]
AID - 10.1017/neu.2014.27 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2014 Dec;26(6):356-63. doi: 10.1017/neu.2014.27. Epub 2014 
      Oct 13.