PMID- 25308531
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 14
IP  - 2
DP  - 2015 Feb
TI  - Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent 
      acute pericarditis.
PG  - 90-7
LID - S1568-9972(14)00217-1 [pii]
LID - 10.1016/j.autrev.2014.10.005 [doi]
AB  - Autoimmunity and autoinflammation are generally considered as mutually exclusive 
      mechanisms of diseases but may concur to specific syndromes. Idiopathic recurrent 
      acute pericarditis (IRAP) is defined as the recurrence of pericardial symptoms at 
      any point following the prior cessation of acute pericarditis, and the latency is 
      generally 6 weeks. Manifestations of pericarditis such as pericardial friction 
      rub, electrocardiographic changes, and pericardial effusion are less frequent in 
      the subsequent episodes compared to the index attack, and in some cases the only 
      clinical sign is represented by a suggestive chest pain. Several autoimmune 
      diseases may manifest with pericarditis which is often related to viral 
      infections, while postviral pericarditis may in turn display a nonspecific 
      autoimmune background. Similarly, autoinflammatory syndromes such as familial 
      Mediterranean fever and tumor necrosis factor receptor-associated periodic 
      syndrome are characterized by self-limiting pericardial symptoms. Corticosteroids 
      are generally effective, thus supporting the autoimmune nature of IRAP, but 
      dramatic results are obtained with interleukin-1 blocking agents in 
      corticosteroid-dependent cases, pointing to a pathogenic role for the 
      inflammasome. Based on these observations, we submit that IRAP represents a 
      paradigmatic example of the putative coexistence of autoimmunity and 
      autoinflammation: the main aim of this review is to critically discuss the 
      hypothesis as well as the current understanding of this enigmatic clinical 
      condition.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Cantarini, Luca
AU  - Cantarini L
AD  - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease 
      Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of 
      Siena, Siena, Italy. Electronic address: cantariniluca@hotmail.com.
FAU - Lopalco, Giuseppe
AU  - Lopalco G
AD  - Interdisciplinary Department of Medicine, Rheumatology Unit, Policlinic Hospital, 
      University of Bari, Bari, Italy.
FAU - Selmi, Carlo
AU  - Selmi C
AD  - Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, 
      Rozzano, Milan, Italy; BIOMETRA Department, University of Milan, Milan, Italy.
FAU - Napodano, Salvatore
AU  - Napodano S
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Rome, Italy.
FAU - De Rosa, Gabriella
AU  - De Rosa G
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Rome, Italy.
FAU - Caso, Francesco
AU  - Caso F
AD  - Research Center of Systemic Autoinflammatory Diseases and Behcet's Disease 
      Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of 
      Siena, Siena, Italy; Department of Clinical and Experimental Medicine, University 
      of Padua, Padua, Italy.
FAU - Costa, Luisa
AU  - Costa L
AD  - Rheumatology Unit, Department of Clinical Medicine and Surgery, University 
      Federico II, Naples, Italy.
FAU - Iannone, Florenzo
AU  - Iannone F
AD  - Interdisciplinary Department of Medicine, Rheumatology Unit, Policlinic Hospital, 
      University of Bari, Bari, Italy.
FAU - Rigante, Donato
AU  - Rigante D
AD  - Institute of Pediatrics, Universita Cattolica Sacro Cuore, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141012
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Acute Disease
MH  - Autoimmune Diseases/immunology
MH  - *Autoimmunity
MH  - Humans
MH  - Inflammation/immunology
MH  - Pericarditis/*immunology
MH  - Recurrence
OTO - NOTNLM
OT  - Anakinra
OT  - Interleukin-1
OT  - Pericardial effusion
OT  - Recurrence
EDAT- 2014/10/14 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/10/14 06:00
PHST- 2014/09/05 00:00 [received]
PHST- 2014/09/23 00:00 [accepted]
PHST- 2014/10/14 06:00 [entrez]
PHST- 2014/10/14 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - S1568-9972(14)00217-1 [pii]
AID - 10.1016/j.autrev.2014.10.005 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2015 Feb;14(2):90-7. doi: 10.1016/j.autrev.2014.10.005. Epub 2014 
      Oct 12.