PMID- 25308798
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20171116
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Mar
TI  - Vaccine adjuvant uses of poly-IC and derivatives.
PG  - 447-59
LID - 10.1586/14760584.2015.966085 [doi]
AB  - Pathogen-associated molecular patterns (PAMPs) are stand-alone immunomodulators 
      or 'danger signals,' that are increasingly recognized as critical components of 
      many modern vaccines. Polyinosinic-polycytidylic acid (poly-IC) is a synthetic 
      dsRNA that can activate multiple elements of the host defense in a pattern that 
      parallels that of a viral infection. When properly combined with an antigen, it 
      can be utilized as a PAMP-adjuvant, resulting in modulation and optimization of 
      the antigen-specific immune response. We briefly review the preclinical and 
      clinical uses of poly-IC and two poly-IC derivatives, poly-IC12U (Ampligen) and 
      poly-ICLC (Hiltonol), as vaccine adjuvants.
FAU - Martins, Karen A O
AU  - Martins KA
AD  - USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702, USA.
FAU - Bavari, Sina
AU  - Bavari S
FAU - Salazar, Andres M
AU  - Salazar AM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20141013
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Vaccines)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage/*pharmacology
MH  - Humans
MH  - Poly I-C/administration & dosage/*pharmacology
MH  - Vaccines/administration & dosage/*immunology
OTO - NOTNLM
OT  - Adaptive immunity
OT  - PAMP
OT  - TLR3
OT  - adjuvant
OT  - ampligen
OT  - hiltonol
OT  - innate immunity
OT  - interferons
OT  - poly-IC
OT  - poly-ICLC
OT  - vaccine
EDAT- 2014/10/14 06:00
MHDA- 2015/10/28 06:00
CRDT- 2014/10/14 06:00
PHST- 2014/10/14 06:00 [entrez]
PHST- 2014/10/14 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - 10.1586/14760584.2015.966085 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2015 Mar;14(3):447-59. doi: 10.1586/14760584.2015.966085. 
      Epub 2014 Oct 13.