PMID- 25309341
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141013
LR  - 20211021
IS  - 1662-5129 (Print)
IS  - 1662-5129 (Electronic)
IS  - 1662-5129 (Linking)
VI  - 8
DP  - 2014
TI  - Dendritic spine dysgenesis in Rett syndrome.
PG  - 97
LID - 10.3389/fnana.2014.00097 [doi]
LID - 97
AB  - Spines are small cytoplasmic extensions of dendrites that form the postsynaptic 
      compartment of the majority of excitatory synapses in the mammalian brain. 
      Alterations in the numerical density, size, and shape of dendritic spines have 
      been correlated with neuronal dysfunction in several neurological and 
      neurodevelopmental disorders associated with intellectual disability, including 
      Rett syndrome (RTT). RTT is a progressive neurodevelopmental disorder associated 
      with intellectual disability that is caused by loss of function mutations in the 
      transcriptional regulator methyl CpG-binding protein 2 (MECP2). Here, we review 
      the evidence demonstrating that principal neurons in RTT individuals and 
      Mecp2-based experimental models exhibit alterations in the number and morphology 
      of dendritic spines. We also discuss the exciting possibility that signaling 
      pathways downstream of brain-derived neurotrophic factor (BDNF), which is 
      transcriptionally regulated by MeCP2, offer promising therapeutic options for 
      modulating dendritic spine development and plasticity in RTT and other 
      MECP2-associated neurodevelopmental disorders.
FAU - Xu, Xin
AU  - Xu X
AD  - Department of Neurobiology, Civitan International Research Center, The University 
      of Alabama at Birmingham, Birmingham, AL USA.
FAU - Miller, Eric C
AU  - Miller EC
AD  - Department of Neurobiology, Civitan International Research Center, The University 
      of Alabama at Birmingham, Birmingham, AL USA.
FAU - Pozzo-Miller, Lucas
AU  - Pozzo-Miller L
AD  - Department of Neurobiology, Civitan International Research Center, The University 
      of Alabama at Birmingham, Birmingham, AL USA.
LA  - eng
GR  - R01 NS065027/NS/NINDS NIH HHS/United States
GR  - R21 HD074418/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140910
PL  - Switzerland
TA  - Front Neuroanat
JT  - Frontiers in neuroanatomy
JID - 101477943
PMC - PMC4159975
OTO - NOTNLM
OT  - BDNF
OT  - MeCP2
OT  - TrkB
OT  - autism spectrum disorder
OT  - excitatory synapse
OT  - hippocampus
OT  - organotypic slice cultures
OT  - spine density
EDAT- 2014/10/14 06:00
MHDA- 2014/10/14 06:01
PMCR- 2014/01/01
CRDT- 2014/10/14 06:00
PHST- 2014/07/19 00:00 [received]
PHST- 2014/08/25 00:00 [accepted]
PHST- 2014/10/14 06:00 [entrez]
PHST- 2014/10/14 06:00 [pubmed]
PHST- 2014/10/14 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnana.2014.00097 [doi]
PST - epublish
SO  - Front Neuroanat. 2014 Sep 10;8:97. doi: 10.3389/fnana.2014.00097. eCollection 
      2014.