PMID- 25309497
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141013
LR  - 20220317
IS  - 1664-1078 (Print)
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 5
DP  - 2014
TI  - A possible link between BDNF and mTOR in control of food intake.
PG  - 1093
LID - 10.3389/fpsyg.2014.01093 [doi]
LID - 1093
AB  - Food intake is intricately regulated by glucose, amino acids, hormones, 
      neuropeptides, and trophic factors through a neural circuit in the hypothalamus. 
      Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor 
      in the brain, regulates differentiation, maturation, and synaptic plasticity 
      throughout life. Among its many roles, BDNF exerts an anorexigenic function in 
      the brain. However, the intracellular signaling induced by BDNF to control food 
      intake is not fully understood. One candidate for the molecule involved in 
      transducing the anorexigenic activity of BDNF is the mammalian target of 
      rapamycin (mTOR). mTOR senses extracellular amino acids, glucose, growth factors, 
      and neurotransmitters, and regulates anabolic reactions response to these 
      signals. Activated mTOR increases protein and lipid synthesis and inhibits 
      protein degradation. In the hypothalamus, mTOR activation is thought to reduce 
      food intake. Here we summarize recent findings regarding BDNF- and mTOR-mediated 
      feeding control, and propose a link between these molecules in eating behavior.
FAU - Takei, Nobuyuki
AU  - Takei N
AD  - Department of Molecular Neurobiology, Brain Research Institute, Niigata 
      University, Niigata Japan.
FAU - Furukawa, Kazuo
AU  - Furukawa K
AD  - Department of Molecular Neurobiology, Brain Research Institute, Niigata 
      University, Niigata Japan ; Department of Hematology, Endocrinology and 
      Metabolism, Faculty of Medicine, Niigata University, Niigata Japan.
FAU - Hanyu, Osamu
AU  - Hanyu O
AD  - Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, 
      Niigata University, Niigata Japan.
FAU - Sone, Hirohito
AU  - Sone H
AD  - Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, 
      Niigata University, Niigata Japan.
FAU - Nawa, Hiroyuki
AU  - Nawa H
AD  - Department of Molecular Neurobiology, Brain Research Institute, Niigata 
      University, Niigata Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140925
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC4174734
OTO - NOTNLM
OT  - AMPK
OT  - BDNF
OT  - body weight
OT  - food intake regulation
OT  - mTOR
OT  - mTORC1
OT  - nutrients
EDAT- 2014/10/14 06:00
MHDA- 2014/10/14 06:01
PMCR- 2014/09/25
CRDT- 2014/10/14 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2014/08/09 00:00 [accepted]
PHST- 2014/10/14 06:00 [entrez]
PHST- 2014/10/14 06:00 [pubmed]
PHST- 2014/10/14 06:01 [medline]
PHST- 2014/09/25 00:00 [pmc-release]
AID - 10.3389/fpsyg.2014.01093 [doi]
PST - epublish
SO  - Front Psychol. 2014 Sep 25;5:1093. doi: 10.3389/fpsyg.2014.01093. eCollection 
      2014.