PMID- 25311779
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20220317
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 159
IP  - 2-3
DP  - 2014 Nov
TI  - Movement abnormalities predict transitioning to psychosis in individuals at 
      clinical high risk for psychosis.
PG  - 263-6
LID - S0920-9964(14)00523-4 [pii]
LID - 10.1016/j.schres.2014.09.031 [doi]
AB  - Improving upon the predictive validity of determining the transition from high 
      risk to actual psychosis is a primary aim of early intervention research. 
      Previous research has suggested that premorbid spontaneous dyskinesias may be one 
      possible predictor. In this study, dyskinetic movements were assessed with the 
      Abnormal Involuntary Movement Scale (AIMS) at baseline of a longitudinal study of 
      148 individuals at clinical high risk (CHR) of developing psychosis. Twenty-eight 
      individuals transitioned to a psychotic disorder over the course of the study. 
      Group comparisons between transitioned and non-transitioned individuals indicated 
      that, relative to those that were not observed to transition, participants that 
      developed a psychotic disorder exhibited greater spontaneous dyskinesias at 
      baseline. Moreover, increased dyskinetic movements at baseline resulted in a more 
      than two-fold increase in odds of developing a psychosis for each point increase 
      in AIMS scale score. These findings suggest that individuals with greater 
      premorbid dyskinetic movements may comprise a subset of CHR individuals at 
      inordinate risk to decompensate into psychosis. Future work should employ 
      assessments of spontaneous dyskinesias by instrumentation (e.g., 
      electromyography) and look to ascertain whether specific dyskinesias (e.g., 
      dystonia) or dyskinesias of specific body regions are associated with 
      transitioning to psychosis.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Callaway, Dallas A
AU  - Callaway DA
AD  - Mathison Centre for Mental Health Research & Education, University of Calgary, 
      Calgary, Alberta, Canada. Electronic address: dacallaw@ucalgary.ca.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. 
      Electronic address: diana_perkins@med.unc.edu.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA. Electronic 
      address: scott.woods@yale.edu.
FAU - Liu, Lu
AU  - Liu L
AD  - Mathison Centre for Mental Health Research & Education, University of Calgary, 
      Calgary, Alberta, Canada. Electronic address: luliu@ucalgary.ca.
FAU - Addington, Jean
AU  - Addington J
AD  - Mathison Centre for Mental Health Research & Education, University of Calgary, 
      Calgary, Alberta, Canada. Electronic address: jmadding@ucalgary.ca.
LA  - eng
GR  - U01MH06634/MH/NIMH NIH HHS/United States
GR  - U01MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - U01MH066160/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141011
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Movement Disorders/*etiology
MH  - Predictive Value of Tests
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*diagnosis
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC4253541
MID - NIHMS631835
OTO - NOTNLM
OT  - Conversion
OT  - Dyskinesia
OT  - Movement abnormality
OT  - Prodromal
OT  - Psychosis
OT  - Schizophrenia
COIS- Conflict of interest There are no conflicts of interest for any of the authors 
      with respect to the data in this paper or for the study.
EDAT- 2014/10/15 06:00
MHDA- 2015/08/20 06:00
PMCR- 2015/11/01
CRDT- 2014/10/15 06:00
PHST- 2014/08/06 00:00 [received]
PHST- 2014/09/18 00:00 [revised]
PHST- 2014/09/21 00:00 [accepted]
PHST- 2014/10/15 06:00 [entrez]
PHST- 2014/10/15 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0920-9964(14)00523-4 [pii]
AID - 10.1016/j.schres.2014.09.031 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Nov;159(2-3):263-6. doi: 10.1016/j.schres.2014.09.031. Epub 
      2014 Oct 11.