PMID- 25312372
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20220408
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Print)
IS  - 1932-8486 (Linking)
VI  - 297
IP  - 11
DP  - 2014 Nov
TI  - Computational fluid dynamics as surgical planning tool: a pilot study on middle 
      turbinate resection.
PG  - 2187-95
LID - 10.1002/ar.23033 [doi]
AB  - Controversies exist regarding the resection or preservation of the middle 
      turbinate (MT) during functional endoscopic sinus surgery. Any MT resection will 
      perturb nasal airflow and may affect the mucociliary dynamics of the osteomeatal 
      complex. Neither rhinometry nor computed tomography (CT) can adequately quantify 
      nasal airflow pattern changes following surgery. This study explores the 
      feasibility of assessing changes in nasal airflow dynamics following partial MT 
      resection using computational fluid dynamics (CFD) techniques. We retrospectively 
      converted the pre- and postoperative CT scans of a patient who underwent isolated 
      partial MT concha bullosa resection into anatomically accurate three-dimensional 
      numerical nasal models. Pre- and postsurgery nasal airflow simulations showed 
      that the partial MT resection resulted in a shift of regional airflow towards the 
      area of MT removal with a resultant decreased airflow velocity, decreased wall 
      shear stress and increased local air pressure. However, the resection did not 
      strongly affect the overall nasal airflow patterns, flow distributions in other 
      areas of the nose, nor the odorant uptake rate to the olfactory cleft mucosa. 
      Moreover, CFD predicted the patient's failure to perceive an improvement in his 
      unilateral nasal obstruction following surgery. Accordingly, CFD techniques can 
      be used to predict changes in nasal airflow dynamics following partial MT 
      resection. However, the functional implications of this analysis await further 
      clinical studies. Nevertheless, such techniques may potentially provide a 
      quantitative evaluation of surgical effectiveness and may prove useful in 
      preoperatively modeling the effects of surgical interventions.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Zhao, Kai
AU  - Zhao K
AD  - Monell Chemical Senses Center, Philadelphia, Pennsylvania; Department of 
      Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania.
FAU - Malhotra, Prashant
AU  - Malhotra P
FAU - Rosen, David
AU  - Rosen D
FAU - Dalton, Pamela
AU  - Dalton P
FAU - Pribitkin, Edmund A
AU  - Pribitkin EA
LA  - eng
GR  - P50 DC006760/DC/NIDCD NIH HHS/United States
GR  - R03 DC008187/DC/NIDCD NIH HHS/United States
GR  - 5R03DC008187/DC/NIDCD NIH HHS/United States
GR  - P50 DC00006760/DC/NIDCD NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Hydrodynamics
MH  - Male
MH  - Nasal Obstruction/diagnostic imaging/surgery
MH  - Paranasal Sinuses/diagnostic imaging/surgery
MH  - *Patient-Specific Modeling
MH  - Pilot Projects
MH  - Tomography, X-Ray Computed
MH  - Turbinates/*diagnostic imaging/*surgery
PMC - PMC4435687
MID - NIHMS623381
OTO - NOTNLM
OT  - 3D model
OT  - computational fluid dynamics
OT  - concha bullosa
OT  - functional endoscopic surgery
OT  - nasal obstruction
OT  - rhinosinusitis
EDAT- 2014/10/15 06:00
MHDA- 2015/06/24 06:00
PMCR- 2015/11/01
CRDT- 2014/10/15 06:00
PHST- 2014/06/24 00:00 [received]
PHST- 2014/06/25 00:00 [accepted]
PHST- 2014/10/15 06:00 [entrez]
PHST- 2014/10/15 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 10.1002/ar.23033 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2014 Nov;297(11):2187-95. doi: 10.1002/ar.23033.