PMID- 25312605
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20220409
IS  - 1464-0694 (Electronic)
IS  - 0960-2011 (Linking)
VI  - 25
IP  - 5
DP  - 2015
TI  - Impact of a cognitive rehabilitation intervention on neuropsychiatric symptoms in 
      mild to moderate Alzheimer's disease.
PG  - 677-707
LID - 10.1080/09602011.2014.964731 [doi]
AB  - The main goal of this study was to evaluate the impact of a cognitive 
      rehabilitation programme on 12 behavioural and psychological symptoms of dementia 
      (BPSD) in patients with mild to moderate Alzheimer's disease (AD). This six-month 
      single-blind block-randomised cross-over controlled study was conducted with 15 
      mild to moderate AD participants and their caregivers. All participants received 
      a four-week home-based cognitive rehabilitation programme to learn/re-learn an 
      instrumental activity of daily living. They were assessed up until three months 
      following the end of the intervention. The Neuropsychiatric Inventory (NPI-12) 
      was employed to evaluate patients' BPSD at seven assessment points during the 
      course of the study. A general linear mixed model analysis performed on the NPI 
      data revealed that aberrant motor behaviours (AMB) increased significantly more 
      in the treatment condition than in the control condition. In addition, both 
      groups registered a significant reduction of delusional symptoms during the 
      second half of the study. Employing a multi-symptom approach to assess 
      participants' BPSD, this cross-over randomised controlled study showed that an 
      individualised cognitive rehabilitation intervention was generally well-tolerated 
      by mild to moderate AD patients. Future cognitive rehabilitation studies 
      conducted with this population should pay attention to AMB symptom changes.
FAU - Brunelle-Hamann, Laurence
AU  - Brunelle-Hamann L
AD  - a Ecole de psychologie , Universite Laval and Centre de recherche de l'Institut 
      Universitaire en Sante Mentale de Quebec , Quebec City , QC , Canada.
FAU - Thivierge, Stephanie
AU  - Thivierge S
FAU - Simard, Martine
AU  - Simard M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20141014
PL  - England
TA  - Neuropsychol Rehabil
JT  - Neuropsychological rehabilitation
JID - 9112672
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*psychology/*rehabilitation
MH  - Cognition
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Single-Blind Method
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Behavioural and psychological symptoms in dementia (BPSD)
OT  - Cognitive rehabilitation
OT  - Instrumental activities of daily living (IADL)
OT  - Neuropsychiatric Inventory
EDAT- 2014/10/15 06:00
MHDA- 2016/04/29 06:00
CRDT- 2014/10/15 06:00
PHST- 2014/10/15 06:00 [entrez]
PHST- 2014/10/15 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 10.1080/09602011.2014.964731 [doi]
PST - ppublish
SO  - Neuropsychol Rehabil. 2015;25(5):677-707. doi: 10.1080/09602011.2014.964731. Epub 
      2014 Oct 14.