PMID- 25314027
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20151119
IS  - 1536-0237 (Electronic)
IS  - 0883-5993 (Linking)
VI  - 29
IP  - 6
DP  - 2014 Nov
TI  - Cardiac magnetic resonance imaging findings predict major adverse events in 
      apical hypertrophic cardiomyopathy.
PG  - 331-9
LID - 10.1097/RTI.0000000000000115 [doi]
AB  - PURPOSE: The purpose of this study was to determine the prognostic significance 
      of cardiac magnetic resonance imaging (MRI) findings in patients with apical 
      hypertrophic cardiomyopathy (HCM). MATERIALS AND METHODS: Cardiac MRI studies of 
      93 consecutive patients with apical HCM were retrospectively evaluated. 
      Quantification of late gadolinium enhancement (LGE) was determined and expressed 
      as a percentage of total left ventricular (LV) myocardial mass (%LGE). 
      Morphologic features including presence of apical aneurysm, right ventricular 
      hypertrophy, and LV thrombus were also assessed. Clinical data were collected 
      during follow-up to assess for occurrence of major adverse events, defined as: 
      heart failure, stroke, appropriate automatic implantable cardioverter 
      defibrillator discharge, sustained ventricular tachycardia, aborted sudden 
      cardiac death, and/or all-cause death. RESULTS: The mean age of the patients was 
      54.9+/-13.8 years, and 72.0% (n=67) were male. LGE, right ventricular hypertrophy, 
      apical aneurysm, and LV thrombus were identified in 69.4%, 25.8%, 18.3%, and 
      4.3%, respectively. Mean %LGE was 10.8%+/-11.1%. Over 2.4+/-1.7 years of follow-up, 
      14 subjects (15.1%) experienced a major adverse event (event rate, 6.3%/y): heart 
      failure (6.5%), stroke (6.5%), appropriate automatic implantable cardioverter 
      defibrillator discharge (2.2%), sustained ventricular tachycardia (2.2%), aborted 
      sudden cardiac death (1.1%), and all-cause death (0.0%). Presence of apical 
      aneurysm and extent of LGE were significant predictors of major adverse events 
      [odds ratio (OR) 4.6, P=0.015; and OR 1.4/5% LGE, P=0.030, respectively]. 
      Patients with both apical aneurysm and >5% LGE were at highest risk for major 
      adverse events (OR 6.7, P=0.004) and had shortest event-free survival (P=0.001). 
      CONCLUSIONS: Within our population of apical HCM patients, the extent of LGE and 
      the presence of an apical aneurysm identified by cardiac MRI were both 
      significant predictors of major adverse clinical events.
FAU - Hanneman, Kate
AU  - Hanneman K
AD  - *Department of Medical Imaging daggerDivision of Cardiology, Peter Munk Cardiac 
      Center, University Health Network, University of Toronto, Toronto, ON, Canada.
FAU - Crean, Andrew M
AU  - Crean AM
FAU - Williams, Lynne
AU  - Williams L
FAU - Moshonov, Hadas
AU  - Moshonov H
FAU - James, Susan
AU  - James S
FAU - Jimenez-Juan, Laura
AU  - Jimenez-Juan L
FAU - Gruner, Christiane
AU  - Gruner C
FAU - Sparrow, Patrick
AU  - Sparrow P
FAU - Rakowski, Harry
AU  - Rakowski H
FAU - Nguyen, Elsie T
AU  - Nguyen ET
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Thorac Imaging
JT  - Journal of thoracic imaging
JID - 8606160
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*diagnosis
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2014/10/15 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/10/15 06:00
PHST- 2014/10/15 06:00 [entrez]
PHST- 2014/10/15 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - 10.1097/RTI.0000000000000115 [doi]
PST - ppublish
SO  - J Thorac Imaging. 2014 Nov;29(6):331-9. doi: 10.1097/RTI.0000000000000115.