PMID- 25314897
OWN - NLM
STAT- MEDLINE
DCOM- 20151231
LR  - 20211021
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 36
IP  - 2
DP  - 2015 Feb
TI  - The exposure to nicotine affects expression of brain-derived neurotrophic factor 
      (BDNF) and nerve growth factor (NGF) in neonate rats.
PG  - 289-95
LID - 10.1007/s10072-014-1934-y [doi]
AB  - In the current study effect of nicotine on expression of neurotrophins, 
      brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) has been 
      studied in hippocampus and frontal cortex during development of brain in rats. 
      Neurotrophins are factors that help in development of brain among which BDNF and 
      NGF are very important, expressed at different stages during the developmental 
      process. Different sedatives are reported to alter the expression of these 
      factors. In this study, three groups of neonate rats (1-5, 5-10 and 10-15 days 
      age) were used each having 20 rats. Ten were subjected to a dose of 66 mug of 
      nicotine while other ten received the same amount of saline at the same time 
      interval. Then expression of the BDNF and NGF was observed in hippocampus and 
      frontal cortex tissue using immunoassay. Western blotting was used to observe the 
      presence of BDNF in hippocampus as well as frontal cortex. In all groups there 
      was a significant decrease in concentration of neurotrophic factors where 
      nicotine was applied as compared to control. The highest expression of BDNF and 
      NGF in hippocampus and frontal cortex was observed in 10-15 days group (G3) and 
      in 5-10 group (G2) as compared to the control, P < 0.01. It was concluded that 
      exposure of neonate rats to nicotine causes a decrease in the expression of NGF 
      and BDNF and it effects the development of brain in neonates that can further 
      impair brain functions.
FAU - Xiaoyu, Wang
AU  - Xiaoyu W
AD  - Medical School of Lishui University, No.1 Xueyuan Road, Lishui, 323000, Zhejiang, 
      China, wangxiouyu500@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20141015
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nicotinic Agonists)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Frontal Lobe/*drug effects/growth & development/metabolism
MH  - Hippocampus/*drug effects/growth & development/metabolism
MH  - Male
MH  - Nerve Growth Factors/*metabolism
MH  - Nicotine/*toxicity
MH  - Nicotinic Agonists/*toxicity
MH  - Rats, Sprague-Dawley
EDAT- 2014/10/16 06:00
MHDA- 2016/01/01 06:00
CRDT- 2014/10/16 06:00
PHST- 2014/07/12 00:00 [received]
PHST- 2014/08/28 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2016/01/01 06:00 [medline]
AID - 10.1007/s10072-014-1934-y [doi]
PST - ppublish
SO  - Neurol Sci. 2015 Feb;36(2):289-95. doi: 10.1007/s10072-014-1934-y. Epub 2014 Oct 
      15.