PMID- 25315164
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Oct 1
TI  - High-resolution 3-dimensional late gadolinium enhancement scar imaging in 
      surgically corrected Tetralogy of Fallot: clinical feasibility of volumetric 
      quantification and visualization.
PG  - 76
LID - 10.1186/s12968-014-0076-y [doi]
LID - 76
AB  - BACKGROUND: The extent of surgical scarring in Tetralogy of Fallot (TOF) may be a 
      marker of adverse outcomes and provide substrate for ventricular arrhythmia. In 
      this study we evaluate the feasibility of high resolution three dimensional (3D) 
      late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) for 
      volumetric scar quantification in patients with surgically corrected TOF. 
      METHODS: Fifteen consecutive patients underwent 3D LGE imaging with 3 Tesla CMR 
      using a whole-heart, respiratory-navigated technique. A novel, signal-histogram 
      based segmentation technique was tested for the quantification and modeling of 
      surgical scar. Total scar volume was compared to the gold standard manual expert 
      segmentation. The feasibility of segmented scar fusion to matched coronary CMR 
      data for volumetric display was explored. RESULTS: Image quality sufficient for 
      3D scar segmentation was acquired in fourteen patients. Mean patient age was 32.2 
      +/- 11.9 years (range 21 to 57 years) with mean right ventricle (RV) ejection 
      fraction (EF) of 53.9 +/- 9.2% and mean RV end diastolic volume of 117.0 +/- 41.5 
      mL/m(2). The mean total scar volume was 11.1 +/- 8.2 mL using semi-automated 3D 
      segmentation with excellent correlation to manual expert segmentation (r = 0.99, 
      bias = 0.89 mL, 95% CI -1.66 to 3.44). The mean segmentation time was 
      significantly reduced using the novel semi-automated segmentation technique 
      (10.1 +/- 2.6 versus 45.8 +/- 12.6 minutes). Excellent intra-observer and good 
      inter-observer reproducibility was observed. CONCLUSION: 3D high resolution LGE 
      imaging with semi-automated scar segmentation is clinically feasible among 
      patients with surgically corrected TOF and shows excellent accuracy and 
      reproducibility. This approach may offer a valuable clinical tool for risk 
      prediction and procedural planning among this growing population.
FAU - Stirrat, John
AU  - Stirrat J
AD  - Imaging Laboratories, Robarts Research Institute, Western University, London, 
      Ontario, Canada. jstirrat2015@meds.uwo.ca.
FAU - Rajchl, Martin
AU  - Rajchl M
AD  - Imaging Laboratories, Robarts Research Institute, Western University, London, 
      Ontario, Canada. mrajchl@robarts.ca.
FAU - Bergin, Lynn
AU  - Bergin L
AD  - Division of Cardiology, Department of Medicine, Western University, Calgary, 
      Canada. Lynn.Bergin@lhsc.on.ca.
FAU - Patton, David J
AU  - Patton DJ
AD  - Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, 
      Calgary, Alberta, Canada. David.Patton@albertahealthservices.ca.
AD  - Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada. 
      David.Patton@albertahealthservices.ca.
FAU - Peters, Terry
AU  - Peters T
AD  - Imaging Laboratories, Robarts Research Institute, Western University, London, 
      Ontario, Canada. tpeters@robarts.ca.
FAU - White, James A
AU  - White JA
AD  - Division of Cardiology, Department of Medicine, Western University, Calgary, 
      Canada. jawhit@ucalgary.ca.
AD  - Cardiac Imaging Centre, Libin Cardiovascular Institute, University of Calgary, 
      Calgary, Alberta, Canada. jawhit@ucalgary.ca.
AD  - Division of Cardiology, Department of Medicine, University of Calgary, Calgary, 
      Alberta, Canada. jawhit@ucalgary.ca.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20141001
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Automation
MH  - *Cardiac Surgical Procedures
MH  - Cicatrix/*diagnosis/etiology/pathology
MH  - *Contrast Media
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - *Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Tetralogy of Fallot/complications/diagnosis/*surgery
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4180957
EDAT- 2014/10/16 06:00
MHDA- 2015/08/25 06:00
PMCR- 2014/10/01
CRDT- 2014/10/16 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/08/28 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - S1097-6647(23)00143-6 [pii]
AID - 76 [pii]
AID - 10.1186/s12968-014-0076-y [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Oct 1;16(1):76. doi: 10.1186/s12968-014-0076-y.