PMID- 25315629
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20220318
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 51
IP  - 6
DP  - 2014 Dec
TI  - Comparison of screening for gestational diabetes mellitus by oral glucose 
      tolerance tests done in the non-fasting (random) and fasting states.
PG  - 1007-13
LID - 10.1007/s00592-014-0660-5 [doi]
AB  - AIM: The Diabetes in Pregnancy Study Group of India (DIPSI) guidelines recommend 
      the non-fasting 75-g oral glucose tolerance test (OGTT) as a single-step 
      screening and diagnostic test for gestational diabetes mellitus (GDM). The aim of 
      this study was to compare the DIPSI criteria with the World Health Organization 
      (WHO) 1999 and the International Association of Diabetes and Pregnancy Study 
      Groups (IADPSG) criteria for GDM. METHODS: A total of 1,031 pregnant women 
      attending antenatal clinics in urban and rural Tamil Nadu, India, underwent a 
      75-g OGTT in both non-fasting and fasting states, 2-3 days apart. Venous plasma 
      glucose was measured using an autoanalyser, and GDM was diagnosed by DIPSI, WHO 
      1999 and IADPSG criteria. RESULTS: Of the 83 women identified to have GDM by WHO 
      1999 criteria, only 23 were diagnosed by DIPSI criteria. Of the 106 women 
      diagnosed to have GDM by the IADPSG criteria, only 24 were diagnosed by DIPSI. 
      The DIPSI non-fasting OGTT 2-h VPG cut point of 140 mg/dl (7.8 mmol/l) had a very 
      low sensitivity when compared to the WHO 1999 criteria (sensitivity 27.7 %, 
      specificity 97.7 %) and IADPSG criteria (sensitivity 22.6 %, specificity 97.8 %). 
      CONCLUSIONS: The DIPSI non-fasting OGTT criteria cannot be recommended for 
      diagnosis of GDM due to its low sensitivity. Thus, as a single-step diagnostic 
      test for GDM, the fasting OGTT needs to be done. When this is not possible, the 
      well-established two-step procedure using the 50-g glucose challenge test as an 
      initial screening test, followed by the diagnostic fasting OGTT, can be 
      continued.
FAU - Mohan, Viswanathan
AU  - Mohan V
AD  - WHO Collaborating Centre for Non Communicable Diseases Prevention and Control and 
      IDF Centre of Education, Madras Diabetes Research Foundation & Dr. Mohan's 
      Diabetes Specialities Centre, 4, Conran Smith Road, Gopalapuram, Chennai, 600 
      086, India, drmohans@diabetes.ind.in.
FAU - Mahalakshmi, Manni Mohanraj
AU  - Mahalakshmi MM
FAU - Bhavadharini, Balaji
AU  - Bhavadharini B
FAU - Maheswari, Kumar
AU  - Maheswari K
FAU - Kalaiyarasi, Gunasekaran
AU  - Kalaiyarasi G
FAU - Anjana, Ranjit Mohan
AU  - Anjana RM
FAU - Uma, Ram
AU  - Uma R
FAU - Usha, Sriram
AU  - Usha S
FAU - Deepa, Mohan
AU  - Deepa M
FAU - Unnikrishnan, Ranjit
AU  - Unnikrishnan R
FAU - Pastakia, Sonak D
AU  - Pastakia SD
FAU - Malanda, Belma
AU  - Malanda B
FAU - Belton, Anne
AU  - Belton A
FAU - Kayal, Arivudainambi
AU  - Kayal A
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141015
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Diabetes, Gestational/blood/*diagnosis
MH  - Fasting/*blood
MH  - Female
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Mass Screening/methods
MH  - Pregnancy
MH  - Prenatal Diagnosis/methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC4239809
EDAT- 2014/10/16 06:00
MHDA- 2015/08/04 06:00
PMCR- 2014/10/15
CRDT- 2014/10/16 06:00
PHST- 2014/07/30 00:00 [received]
PHST- 2014/09/23 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
PHST- 2014/10/15 00:00 [pmc-release]
AID - 660 [pii]
AID - 10.1007/s00592-014-0660-5 [doi]
PST - ppublish
SO  - Acta Diabetol. 2014 Dec;51(6):1007-13. doi: 10.1007/s00592-014-0660-5. Epub 2014 
      Oct 15.