PMID- 25315850
OWN - NLM
STAT- MEDLINE
DCOM- 20160210
LR  - 20220318
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 253
IP  - 9
DP  - 2015 Sep
TI  - Evolution of vitreomacular adhesion to acute vitreofoveal separation with special 
      emphasis on a traction-induced foveal pathology. A prospective study of 
      spectral-domain optical coherence tomography.
PG  - 1425-35
LID - 10.1007/s00417-014-2826-9 [doi]
AB  - PURPOSE: To investigate the evolution of vitreomacular adhesion (VMA) to acute 
      vitreofoveal separation with particular emphasis on cases involving the 
      underlying fovea. METHODS: In this observational case series, of 192 cases in the 
      VMA stage, 51 progressed to acute vitreofoveal separation; this subgroup was 
      divided into those with normal separation (Group I) and those with co-existing 
      macular findings (Group II). All patients were examined using spectral 
      domain-optical coherence tomography (SD-OCT) at regular three-month intervals. We 
      recorded the best-corrected visual acuity (BCVA), the vitreomacular angle of the 
      VMA (nasally and temporally), the horizontal diameter of the VMA, the macular 
      thickness, the integrity of the photoreceptor layer and of the external limiting 
      membrane. The Amsler grid test was used in the intermediate examinations in cases 
      where patients developed symptoms. RESULTS: Out of the 51 cases in the VMA stage, 
      45 (88.2%) progressed to normal spontaneous vitreofoveal separation, while six 
      (11.8%) developed findings of the fovea, such as macular thinning (two cases), an 
      anomalous foveal contour (two cases), a macular tissue defect (one case) and 
      vitreous separation from only the temporal side of the VMA in one case. Foveal 
      findings were the same during the follow-up period in all but one case in which 
      improvement was noted. Differences in BCVA between baseline measurements, those 
      made immediately after vitreofoveal separation, and those made during final 
      examination were not statistically significant. For the whole sample of our study 
      (51 cases), the mean observation time at the VMA stage was 21.8 +/-10.6 months, 
      while the mean follow-up time after vitreofoveal separation was 9.7 +/-4.9 months. 
      In cases that developed incidents from the fovea, the mean observation time from 
      the baseline to the last examination before vitreofoveal separation was 
      16.5 +/-11.2 months and the mean follow-up time from the diagnosis of vitreofoveal 
      separation to the final examination was 8.5 +/-4.4 months. CONCLUSIONS: VMA, 
      excepting its progression to vitreomacular traction or spontaneous release, in a 
      subset of patients can also cause findings associated with the fovea, 
      concomitantly with vitreofoveal separation. Vitreofoveal separation can induce 
      unilateral anatomic distortion of the fovea accompanied by symptoms, such as 
      metamorphopsia or micropsia.
FAU - Theodossiadis, George P
AU  - Theodossiadis GP
AD  - 2nd Department of Ophthalmology, Henry Dunant Hospital, 13 Lykiou street, 10674, 
      Athens, Greece, theodossiadisg@ath.forthnet.gr.
FAU - Chatziralli, Irini P
AU  - Chatziralli IP
FAU - Sergentanis, Theodoros N
AU  - Sergentanis TN
FAU - Datseris, Ioannis
AU  - Datseris I
FAU - Theodossiadis, Panagiotis G
AU  - Theodossiadis PG
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20141015
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - Retinal Diseases/*diagnosis
MH  - Tissue Adhesions/diagnosis
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Vitreous Body/*pathology
MH  - Vitreous Detachment/*diagnosis
EDAT- 2014/10/16 06:00
MHDA- 2016/02/11 06:00
CRDT- 2014/10/16 06:00
PHST- 2014/06/22 00:00 [received]
PHST- 2014/09/30 00:00 [accepted]
PHST- 2014/09/06 00:00 [revised]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2016/02/11 06:00 [medline]
AID - 10.1007/s00417-014-2826-9 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2015 Sep;253(9):1425-35. doi: 
      10.1007/s00417-014-2826-9. Epub 2014 Oct 15.