PMID- 25315860
OWN - NLM
STAT- MEDLINE
DCOM- 20150317
LR  - 20220409
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 35
IP  - 1
DP  - 2015 Jan
TI  - Cerebral perfusion in insulin resistance and type 2 diabetes.
PG  - 95-102
LID - 10.1038/jcbfm.2014.173 [doi]
AB  - Cerebral perfusion was evaluated in 87 subjects prospectively enrolled in three 
      study groups-healthy controls (HC), patients with insulin resistance (IR) but not 
      with diabetes, and type 2 diabetes mellitus (T2DM). Participants received a 
      comprehensive 8-hour clinical evaluation and arterial spin labeling magnetic 
      resonance imaging (MRI). In order of decreasing significance, an association was 
      found between cerebral blood flow (CBF) and sex, waist circumference, diastolic 
      blood pressure (BP), end tidal CO2, and verbal fluency score (R(2)=0.27, F=5.89, 
      P<0.001). Mean gray-matter CBF in IR was 4.4 mL/100 g per minute lower than in 
      control subjects (P=0.005), with no hypoperfusion in T2DM (P=0.312). Subjects 
      with IR also showed no CO2 relationship (slope=-0.012) in the normocapnic range, 
      in contrast to a strong relationship in healthy brains (slope=0.800) and 
      intermediate response (slope=0.445) in diabetic patients. Since the majority of 
      T2DM but few IR subjects were aggressively treated with blood glucose, 
      cholesterol, and BP lowering medications, our finding could be attributed to the 
      beneficial effect of these drugs.
FAU - Rusinek, Henry
AU  - Rusinek H
AD  - Department of Radiology, NYU School of Medicine, New York, New York, USA.
FAU - Ha, Jenny
AU  - Ha J
AD  - Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
FAU - Yau, Po Lai
AU  - Yau PL
AD  - Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
FAU - Storey, Pippa
AU  - Storey P
AD  - Department of Radiology, NYU School of Medicine, New York, New York, USA.
FAU - Tirsi, Aziz
AU  - Tirsi A
AD  - Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
FAU - Tsui, Wai Hon
AU  - Tsui WH
AD  - Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
FAU - Frosch, Olivia
AU  - Frosch O
AD  - NYU School of Medicine, New York, New York, USA.
FAU - Azova, Svetlana
AU  - Azova S
AD  - NYU School of Medicine, New York, New York, USA.
FAU - Convit, Antonio
AU  - Convit A
AD  - 1] Department of Psychiatry, NYU School of Medicine, New York, New York, USA [2] 
      Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
LA  - eng
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - R01 DK064087/DK/NIDDK NIH HHS/United States
GR  - DK064087/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20141015
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Analysis of Variance
MH  - Blood Flow Velocity/physiology
MH  - Case-Control Studies
MH  - Cerebrovascular Circulation/*physiology
MH  - Cognition/physiology
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology/psychology
MH  - Female
MH  - Humans
MH  - *Insulin Resistance/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC4294398
EDAT- 2014/10/16 06:00
MHDA- 2015/03/18 06:00
PMCR- 2016/01/01
CRDT- 2014/10/16 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2014/08/19 00:00 [revised]
PHST- 2014/09/10 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/03/18 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - jcbfm2014173 [pii]
AID - 10.1038/jcbfm.2014.173 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2015 Jan;35(1):95-102. doi: 10.1038/jcbfm.2014.173. 
      Epub 2014 Oct 15.