PMID- 25316199
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20151119
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 13
IP  - 12
DP  - 2014 Dec 5
TI  - Serum metabolomics study and eicosanoid analysis of childhood atopic dermatitis 
      based on liquid chromatography-mass spectrometry.
PG  - 5715-23
LID - 10.1021/pr5007069 [doi]
AB  - Atopic dermatitis (AD) is the most common inflammatory skin disease in children. 
      In the study, ultra high performance liquid chromatography-mass spectrometry was 
      used to investigate serum metabolic abnormalities of AD children. Two batch 
      fasting sera were collected from AD children and healthy control; one of them was 
      for nontargeted metabolomics analysis, the other for targeted eicosanoids 
      analysis. AD children were divided into high immunoglobulin E (IgE) group and 
      normal IgE group. On the basis of the two analysis approaches, it was found that 
      the differential metabolites of AD, leukotriene B4, prostaglandins, conjugated 
      bile acids, etc., were associated with inflammatory response and bile acids 
      metabolism. Carnitines, free fatty acids, lactic acid, etc., increased in the AD 
      group with high IgE, which revealed energy metabolism disorder. Amino acid 
      metabolic abnormalities and increased levels of Cytochrome P450 epoxygenase 
      metabolites were found in the AD group with normal IgE. The results provided a 
      new perspective to understand the mechanism and find potential biomarkers of AD 
      and may provide a new reference for personalized treatment.
FAU - Huang, Yan
AU  - Huang Y
AD  - Dalian Children's Hospital , Dalian 116011, China.
FAU - Chen, Guoyou
AU  - Chen G
FAU - Liu, Xinyu
AU  - Liu X
FAU - Shao, Yaping
AU  - Shao Y
FAU - Gao, Peng
AU  - Gao P
FAU - Xin, Chenchen
AU  - Xin C
FAU - Cui, Zhenze
AU  - Cui Z
FAU - Zhao, Xinjie
AU  - Zhao X
FAU - Xu, Guowang
AU  - Xu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141024
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Biomarkers)
RN  - 0 (Eicosanoids)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Prostaglandins)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Bile Acids and Salts/blood
MH  - Biomarkers/blood
MH  - Carnitine/blood
MH  - Child, Preschool
MH  - Chromatography, Liquid/*methods
MH  - Dermatitis, Atopic/blood/diagnosis/*metabolism
MH  - Eicosanoids/blood/*metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Lactic Acid/blood
MH  - Leukotriene B4/blood
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Metabolome
MH  - Metabolomics/*methods
MH  - Prostaglandins/blood
MH  - ROC Curve
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - LC-MS,
OT  - eicosanoids
OT  - immunoglobulin E
OT  - metabolomics
EDAT- 2014/10/16 06:00
MHDA- 2015/10/27 06:00
CRDT- 2014/10/16 06:00
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
AID - 10.1021/pr5007069 [doi]
PST - ppublish
SO  - J Proteome Res. 2014 Dec 5;13(12):5715-23. doi: 10.1021/pr5007069. Epub 2014 Oct 
      24.