PMID- 25316720
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20220408
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 11
DP  - 2014 Oct 14
TI  - Macular choroidal thickness in unilateral amblyopic children.
PG  - 7361-8
LID - 10.1167/iovs.14-14439 [doi]
AB  - PURPOSE: To investigate the choroidal thickness (CT) in children with amblyopia 
      through spectral-domain optical coherence tomography (SD-OCT). METHODS: 
      Thirty-seven children with unilateral amblyopia and 22 children with normal 
      vision participated in the study. Cross-sectional images of the choroid of 
      evaluated eyes were obtained by SD-OCT. The choroidal thickness was measured 
      directly below the fovea and at eight other locations: 1 and 2 mm superior, 
      temporal, inferior, and nasal to the fovea. The researchers compared the 
      choroidal thickness among amblyopic eyes, fellow eyes of children with amblyopia, 
      and the eyes of children with normal vision. Age, sex, refractive error, axial 
      length, and best-corrected visual acuity were also recorded. A paired t-test was 
      used to compare measurements between amblyopic eyes and fellow eyes in patients 
      with amblyopia. A generalized estimating equation (GEE) was used to compare 
      measurements among amblyopic eyes, fellow eyes, and control eyes, adjusting for 
      the possible effects of age, sex, and axial length on CT. The correlation between 
      choroidal thickness and other continuous variables was determined using the 
      Pearson correlation coefficient. RESULTS: The choroidal thickness at the fovea, 1 
      and 2 mm superior, 1 mm inferior, 1 mm nasal, and 1 mm temporal to the fovea was 
      greater in amblyopic eyes and in fellow eyes of children with amblyopia than in 
      the eyes of children with normal vision. The choroidal thickness at the fovea and 
      2 mm nasal to the fovea in amblyopic eyes was greater (P = 0.002, P = 0.043) than 
      in the fellow eyes of the children with amblyopia. The subfoveal CT in amblyopic 
      eyes negatively correlated with axial length (r = -0.501, P = 0.002), but did not 
      correlate with spherical equivalent, logMAR visual acuity, or age. CONCLUSIONS: 
      In the subfoveal area, the choroid was thicker in amblyopic eyes than in fellow 
      eyes in children with amblyopia. Furthermore, differences were found in the 
      choroidal thickness in both eyes of children with amblyopia compared with 
      participants with normal vision. A thicker choroid is somehow related to 
      amblyopia, and this may be a useful diagnostic parameter for amblyopia.
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Xu, Jinling
AU  - Xu J
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Zheng, Jingwei
AU  - Zheng J
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Yu, Shujuan
AU  - Yu S
AD  - Qilu Children's Hospital of Shandong University, Jinan, Shandong, China.
FAU - Sun, Zuhua
AU  - Sun Z
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Zheng, Weiwei
AU  - Zheng W
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Qu, Peng
AU  - Qu P
AD  - Department of Ophthalmology, Shandong Provincial Qianfoshan Hospital, Shandong 
      University, Jinan, Shandong, China.
FAU - Chen, Yuanyuan
AU  - Chen Y
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Chen, Wuhe
AU  - Chen W
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Yu, Xinping
AU  - Yu X
AD  - Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141014
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Amblyopia/*diagnosis/physiopathology
MH  - Child
MH  - Choroid/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
OTO - NOTNLM
OT  - OCT
OT  - amblyopia
OT  - choroidal thickness
EDAT- 2014/10/16 06:00
MHDA- 2015/01/07 06:00
CRDT- 2014/10/16 06:00
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
AID - iovs.14-14439 [pii]
AID - 10.1167/iovs.14-14439 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Oct 14;55(11):7361-8. doi: 10.1167/iovs.14-14439.