PMID- 25317165
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141015
LR  - 20220316
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 9
IP  - 16
DP  - 2014 Aug 15
TI  - Possible protective action of neurotrophic factors and natural compounds against 
      common neurodegenerative diseases.
PG  - 1506-8
LID - 10.4103/1673-5374.139474 [doi]
AB  - It has been suggested that altered levels/function of brain-derived neurotrophic 
      factor (BDNF) play a role in the pathophysiology of neurodegenerative diseases 
      including Alzheimer's disease. BDNF positively contributes to neural survival and 
      synapse maintenance via stimulating its high affinity receptor TrkB, making 
      upregulation of BDNF and/or activation of BDNF-related intracellular signaling an 
      attractive approach to treating neurodegenerative diseases. In this short review, 
      I briefly introduce small natural compounds such as flavonoids that successfully 
      increase activation of the BDNF system and discuss their beneficial effects 
      against neurodegeneration.
FAU - Numakawa, Tadahiro
AU  - Numakawa T
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4192965
OTO - NOTNLM
OT  - BDNF
OT  - TrkB
OT  - natural compounds
OT  - neurodegenerative diseases
OT  - neuroprotection
COIS- Conflicts of interest: None declared.
EDAT- 2014/10/16 06:00
MHDA- 2014/10/16 06:01
PMCR- 2014/08/15
CRDT- 2014/10/16 06:00
PHST- 2014/06/28 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2014/10/16 06:01 [medline]
PHST- 2014/08/15 00:00 [pmc-release]
AID - NRR-9-1506 [pii]
AID - 10.4103/1673-5374.139474 [doi]
PST - ppublish
SO  - Neural Regen Res. 2014 Aug 15;9(16):1506-8. doi: 10.4103/1673-5374.139474.