PMID- 25318079
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20141203
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 75
IP  - 12
DP  - 2014 Dec
TI  - Non-classical MHC-I human leukocyte antigen (HLA-G) in hepatotropic viral 
      infections and in hepatocellular carcinoma.
PG  - 1225-31
LID - S0198-8859(14)00459-5 [pii]
LID - 10.1016/j.humimm.2014.09.019 [doi]
AB  - The human leukocyte antigen (HLA)-G is a "nonclassical" major histocompatibility 
      complex (MHC) class Ib gene, located at chromosome 6, in the 6p21.3 region. The 
      HLA-G presents immunomodulatory functions essential in pregnancy for the 
      tolerance of the semi-allogenic fetus, but an abnormal expression of HLA-G has 
      been observed in numerous pathological conditions, such as tumors, autoimmune 
      diseases and viral infections. In recent years, numerous studies have assessed 
      the clinical relevance of HLA-G expression in different types of cancer: in 
      general, a higher HLA-G expression correlates with a lower survival rate or a 
      shorter disease-free survival. Altered expression of HLA-G has been found in both 
      HCV and HBV infection, and some genetic polymorphisms have been associated with 
      altered susceptibility/disease development for these infections, however, whether 
      the biologic role of HLA-G in HCV and HBV infection is beneficial or hazardous, 
      it is not completely clear. In the context of hepatocellular carcinoma, HLA-G has 
      shown a potential diagnostic role, moreover a prognostic value in HCC patients 
      has been also attributed to HLA-G molecules. We revise here the role of HLA-G in 
      hepatotropic HBV/HCV infections and in hepatocellular carcinoma (HCC).
CI  - Copyright (c) 2014 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Catamo, Eulalia
AU  - Catamo E
AD  - Medical Science Department, University of Trieste, Italy.
FAU - Zupin, Luisa
AU  - Zupin L
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
FAU - Crovella, Sergio
AU  - Crovella S
AD  - Medical Science Department, University of Trieste, Italy; Institute for Maternal 
      and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
FAU - Celsi, Fulvio
AU  - Celsi F
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
FAU - Segat, Ludovica
AU  - Segat L
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy. 
      Electronic address: ludovica.segat@burlo.trieste.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141012
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Carcinoma, Hepatocellular/*immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics/immunology
MH  - Hepatitis B/genetics/*immunology
MH  - Hepatitis C/genetics/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Liver Neoplasms/*immunology
MH  - Polymorphism, Genetic
MH  - Pregnancy
OTO - NOTNLM
OT  - HBV
OT  - HCV
OT  - HLA-G
OT  - Hepatocellular carcinoma
EDAT- 2014/10/16 06:00
MHDA- 2015/08/01 06:00
CRDT- 2014/10/16 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/09/27 00:00 [revised]
PHST- 2014/09/27 00:00 [accepted]
PHST- 2014/10/16 06:00 [entrez]
PHST- 2014/10/16 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - S0198-8859(14)00459-5 [pii]
AID - 10.1016/j.humimm.2014.09.019 [doi]
PST - ppublish
SO  - Hum Immunol. 2014 Dec;75(12):1225-31. doi: 10.1016/j.humimm.2014.09.019. Epub 
      2014 Oct 12.